Multiple short bouts of exercise over 12-h period reduce glucose excursions more than an energy-matched single bout of exercise.
Multiple short bouts of exercise over 12-h period reduce glucose excursions more than an energy-matched single bout of exercise.
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DOI：
10.1016/j.metabol.2013.12.006
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发表时间：
2014-04
影响因子：
9.8
通讯作者：
Kanaley, Jill
中科院分区：
文献类型：
--
作者：
Holmstrup, Michael;Fairchild, Timothy;Keslacy, Stefan;Weinstock, Ruth;Kanaley, Jill
长时间不间断的久坐行为被认为会对餐后葡萄糖和胰岛素浓度产生负面影响。我们研究了1小时的晨练与间歇性短时间步行对12小时内葡萄糖漂移和胰岛素分泌的影响。11名年轻肥胖个体（18-35y， BMI>30kg/m2）糖耐量受损，在3个12小时的研究日进行研究：1)久坐行为（SED）；2)久坐行为，1小时的晨练（EX）在60-65%的vo2峰值；3)以60-65%的vo2峰值进行12小时，5分钟的运动（INT）的久坐行为。每2 h提供一餐（1046千焦/餐）。每10分钟采集一次血样，测定葡萄糖、胰岛素和c肽浓度。与EX组相比，INT组和SED组葡萄糖iAUC （12 h）降低（P<0.05）。与SED相比，EX组的葡萄糖浓度在约150分钟（研究日的20%）内较高，与EX- int组的研究日相比，葡萄糖浓度在约240分钟（12小时的约1/3）内较高。SED组12 h胰岛素iAUC较INT组和EX组高约15% （P<0.05）。与SED和EX组相比，INT组胰岛素生成率增加了约20% （P<0.05）。短时间、频繁的运动比在早晨连续进行等量的运动更能降低肥胖个体的葡萄糖漂移和胰岛素浓度。
Long, uninterrupted bouts of sedentary behavior are thought to negatively influence postprandial glucose and insulin concentrations. We examined the effects of a 1-h bout of morning exercise versus intermittent walking bouts of short duration on glucose excursions and insulin secretion over 12-h. Eleven young, obese individuals (18–35y, BMI>30kg/m2) with impaired glucose tolerance were studied on three 12-h study days: 1) sedentary behavior (SED); 2) sedentary behavior with 1-h morning exercise (EX) at 60–65% VO2peak; and 3) sedentary behavior with 12-hourly, 5-min intervals of exercise (INT) at 60–65% VO2peak. Meals (1046 kJ/meal) were provided every 2-h. Blood samples were collected every 10 min and measured for glucose, insulin, and c-peptide concentrations. Glucose iAUC (12-h) was attenuated in the INT and SED conditions compared to the EX condition (P<0.05). Glucose concentrations were higher in the EX compared to the SED condition for ~150 min (20% of the study day), and comparison of the EX-INT study days revealed that glucose concentrations were greater for ~ 240 minutes (~1/3 of the 12-h day). In the SED condition, the 12-h insulin iAUC was ~15% higher (P<0.05) compared to the INT and EX conditions. Insulin production rate was found to increase ~20% with INT exercise vs. the SED and EX condition (P<0.05). Short, frequent periods of exercise attenuated glucose excursions and insulin concentrations in obese individuals to a greater degree than an equal amount of exercise performed continuously in the morning.
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影响因子：
16.2
作者：
Dunstan DW;Kingwell BA;Larsen R;Healy GN;Cerin E;Hamilton MT;Shaw JE;Bertovic DA;Zimmet PZ;Salmon J;Owen N
通讯作者：
Owen N
影响因子：
16.2
作者：
van Dijk, Jan-Willeni;Tummers, Kyra;van Loon, Luc J. C.
通讯作者：
van Loon, Luc J. C.
影响因子：
9.8
作者：
LEVITT, NS;HIRSCH, L;POLONSKY, KS
通讯作者：
POLONSKY, KS
影响因子：
16.2
作者：
Jovanovic A;Gerrard J;Taylor R
通讯作者：
Taylor R
影响因子：
3.5
作者：
WOLEVER, TMS;JENKINS, DJA;JOSSE, RG
通讯作者：
JOSSE, RG