The ABC-associated Immunosenescence and Lifestyle Interventions in Autoimmune Disease.

The ABC-associated Immunosenescence and Lifestyle Interventions in Autoimmune Disease.
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DOI:
10.2478/rir-2022-0021
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发表时间:
2022-10
期刊:
Rheumatology and immunology research
影响因子:
--
通讯作者:
Wu, Haijing
Wu, Haijing
中科院分区:
其他
文献类型:
--
作者:
Ruan, Pinglang;Wang, Susu;Yang, Ming;Wu, Haijing

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衰老相关的免疫变化,称为免疫衰老,发生与受损的强大的免疫反应。这种免疫反应与自身免疫性疾病(AID)发展的更大风险密切相关,这导致自身抗体水平增加,发病率和死亡率增加。此外,生活方式相关的危险因素在AID中起着关键作用,这可能是通过衰老相关的免疫细胞亚群。在患有类风湿性关节炎(RA)、系统性红斑狼疮(SLE)和多发性硬化症(MS)的患者中已经观察到了T细胞相关的B细胞(ABC)亚群。在这里,这篇综述的目的是强调艾滋病的ABC与生活方式干预的机制,特别是免疫衰老如何影响艾滋病的发病机制和未来的衰老相关的生活方式干预艾滋病的免疫衰老。
Aging-associated immune changes, termed immunosenescence, occur with impaired robust immune responses. This immune response is closely related to a greater risk of development of autoimmune disease (AID), which results in increased levels of autoantibodies and increased morbidity and mortality. In addition, lifestyle-related risk factors play a pivotal role in AID, which may be probable via senescence-related immune cell subsets. Age-associated B cell (ABC) subsets have been observed in those who have rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and multiple sclerosis (MS). Here, this review aims to highlight the mechanisms of ABCs with lifestyle interventions in AID, especially how immunosenescence affects the pathogenesis of AID and the future of aging-associated lifestyle interventions in immunosenescence of AID.
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