Phase advance with separate and combined melatonin and light treatment
Phase advance with separate and combined melatonin and light treatment
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单独和组合褪黑激素和光治疗的阶段推进
DOI：
10.1007/s00213-010-2059-5
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发表时间：
2011
影响因子：
3.4
通讯作者：
J. Arendt
中科院分区：
文献类型：
--
作者：
M. A. Paul;G. Gray;H. Lieberman;R. Love;James C. Miller;Matthew Trouborst;J. Arendt
建议使用褪黑激素和光照治疗，以加速适应时区变化。我们评估了下午方案的3毫克持续释放（SR）褪黑激素与和没有第二天早上绿色光治疗的昼夜节律相位提前。褪黑激素和光的影响分别进行了测试，然后结合起来，以确定是否总的相位变化是添加剂或synergistic.Material和methodsFor每一个条件（褪黑激素，安慰剂，光，褪黑激素加光），11名受试者花了从周二晚上到周五下午在实验室。对于所有四种情况，保持以下睡眠时间表：第1晚，2345至0630小时，第2晚，1600至0530小时，第3晚，2345至0700小时。对于仅光照条件，周四0700至0800之间进行光照处理。对于仅使用褪黑激素或安慰剂的情况，在周三16：00时给予胶囊。对于组合条件，褪黑激素在星期三1600时施用，在星期四0600和0700之间进行光处理。通过使用平均基线+2标准差（BL + 2 SD）阈值从唾液褪黑激素计算昏暗光褪黑激素起始（DLMO）来评估昼夜节律时相。对于所有四种情况，治疗前和治疗后DLMO评估分别在周二和周四晚上进行。褪黑激素在1600小时，0.72小时P < 0.005，从0700到0800小时的光处理，0.31小时，不显著，并且组合处理，1.04 h p <0.0002。结论下午褪黑素与次日早晨光照联合作用，相位提前是相加的。
IntroductionMelatonin and light treatment are recommended for hastening adaptation to time zone change. We evaluated an afternoon regimen of 3 mg sustained release (SR) melatonin with and without next morning green light treatment for circadian phase advance. Effects of melatonin and light were tested separately and then combined to determine if the total phase change is additive or synergistic.Material and methodsFor each condition (melatonin, placebo, light, melatonin plus light), 11 subjects spent from Tuesday evening until Friday afternoon in the laboratory. For all four conditions, the following sleep schedule was maintained: night 1, 2345 to 0630 hours, night 2, 1600 to 0530 hours, and night 3, 2345 to 0700 hours. For the light-only condition, light treatment was administered between 0700 and 0800 hours on Thursday. For melatonin-only or placebo conditions, capsules were administered at 1600 hours on Wednesday. For the combined condition, melatonin was administered at 1600 hours on Wednesday with light treatment between 0600 and 0700 hours on Thursday. Circadian phase was assessed by calculating dim light melatonin onset (DLMO) from salivary melatonin, using a mean baseline +2 standard deviations (BL + 2 SD) threshold. For all four conditions, pre-treatment and post-treatment DLMO assessments were on Tuesday and Thursday evenings, respectively.ResultsPhase advances were: melatonin at 1600 hours, 0.72 h p < 0.005, light treatment from 0700 to 0800 hours, 0.31 h, non-significant, and the combined treatment, 1.04 h p < 0.0002.ConclusionThe phase advance from the combination of afternoon melatonin with next morning light is additive.
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影响因子：
2.8
作者：
Lewy, AJ;Bauer, VK;Sack, RL
通讯作者：
Sack, RL
褪黑激素和光在人体昼夜节律系统中的作用。
影响因子：
--
作者：
Lewy,AJ;Sack,RL
通讯作者：
Sack,RL
影响因子：
2.8
作者：
LEWY, AJ;SACK, RL
通讯作者：
SACK, RL
影响因子：
2.8
作者：
Eastman, Charmane I;Burgess, Helen J
通讯作者：
Burgess, Helen J
昼夜节律。
DOI：
10.1016/b978-0-12-571149-4.50007-6
发表时间：
1994
期刊：
Recent progress in hormone research
影响因子：
--
作者：
Turek,FW
通讯作者：
Turek,FW