Novelty-induced conditioned place preference, sucrose preference, and elevated plus maze behavior in adult rats after repeated exposure to methylphenidate during the preweanling period.
Novelty-induced conditioned place preference, sucrose preference, and elevated plus maze behavior in adult rats after repeated exposure to methylphenidate during the preweanling period.
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DOI：
10.1016/j.bbr.2013.02.031
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发表时间：
2013-06-01
影响因子：
2.7
通讯作者：
Kozanian, Olga O.
中科院分区：
文献类型：
--
作者：
Crawford, Cynthia A.;Der-Ghazarian, Taleen;Britt, Cynthia E.;Varela, Fausto A.;Kozanian, Olga O.
早期使用哌醋甲酯对成年大鼠和小鼠的情感(即焦虑和抑郁样)行为有持久的影响。有趣的是，暴露于哌醋甲酯时的年龄似乎是影响情感行为表达的关键决定因素。在本研究中，我们让大鼠在断奶前阶段(即PD 11-PD 20)暴露于哌醋甲酯，因为这一个体发育期类似于人类的童年早期(这一年龄与哌酸甲酯使用量的增加有关)。大鼠从PD 11到PD 20注射哌醋甲酯(0、2或5 mg/kg)，并在成年早期测量对奖赏和厌恶刺激的反应性。具体地说，在PD 60上评估了新奇诱导的CPP、蔗糖偏好和升高+迷宫行为。早期使用2 mg/kg或5 mg/kg的哌醋甲酯可增加在CPP舱的白色隔室中停留的总时间。无论暴露条件如何，这种由哌醋甲酯诱导的效应都会发生。在高架PLUS迷宫中的表现也受到早期暴露的影响，因为服用5 mg/kg哌醋甲酯的大鼠在高架PLUS迷宫的封闭隔间中花费的时间比车辆对照组多。早期暴露于哌醋甲酯并没有改变对蔗糖的偏好。这些数据表明，在断奶前让大鼠暴露于哌醋甲酯会对焦虑样行为产生不同的影响，这取决于引发焦虑的刺激的类型。具体地说，当在新奇诱导的CPP任务中测量时，早期暴露于哌醋甲酯降低了对明亮白色房间的厌恶，而当在高架+迷宫中测量时，哌醋甲酯导致焦虑的长期增加。
Early treatment with methylphenidate has a persistent effect on the affective (i.e., anxiety- and depressive-like) behaviors of adult rats and mice. Interestingly, age at methylphenidate exposure appears to be a critical determinant influencing the expression of affective behaviors. In the present study, we exposed rats to methylphenidate during the preweanling period (i.e., PD 11-PD 20) because this ontogenetic period is analogous to early childhood in humans (an age associated with increasing methylphenidate usage). Rats were injected with methylphenidate (0, 2, or 5 mg/kg) from PD 11 to PD 20 and reactivity to rewarding and aversive stimuli were measured in early adulthood. Specifically, novelty-induced CPP, sucrose preference, and elevated plus maze behavior were assessed on PD 60. Early treatment with 2 or 5 mg/kg methylphenidate increased total time spent in the white compartment of the CPP chamber. This methylphenidate-induced effect occurred regardless of exposure condition. Performance on the elevated plus maze was also impacted by early methylphenidate exposure, because rats treated with 5 mg/kg methylphenidate spent more time in the closed compartment of the elevated plus maze than vehicle controls. Early methylphenidate exposure did not alter sucrose preference. These data indicate that exposing rats to methylphenidate during the preweanling period differentially affects anxiety-like behavior depending on the type of anxiety-provoking stimulus. Specifically, early methylphenidate exposure decreased aversion to a bright white room when measured on a novelty-induced CPP task, whereas methylphenidate caused a long-term increase in anxiety when measured on the elevated plus maze.
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DOI：
10.1016/j.pbb.2008.11.011
发表时间：
2009-03
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Halladay LR;Iñiguez SD;Furqan F;Previte MC;Chisum AM;Crawford CA
通讯作者：
Crawford CA
影响因子：
10.6
作者：
Carlezon, WA;Mague, SD;Andersen, SL
通讯作者：
Andersen, SL
影响因子：
2.2
作者：
Britton, Gabrielle B.;Segan, Andrew T.;Mancebo, Silvia E.
通讯作者：
Mancebo, Silvia E.
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL
影响因子：
7.6
作者：
Brandon, CL;Marinelli, M;White, FJ
通讯作者：
White, FJ