Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain.
Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain.
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DOI：
10.1007/s12035-008-8034-z
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发表时间：
2008-08
影响因子：
5.1
通讯作者：
Mermelstein, Paul G.
中科院分区：
文献类型：
--
作者：
Micevych, Paul E.;Mermelstein, Paul G.
自从第一批描述类固醇激素对大脑功能影响的研究发表以来，已经过去了60多年。30多年来，人们一直认为雌激素通过特定受体直接影响基因表达和蛋白质合成。20多年前，第一个雌激素受体被克隆并确定为转录因子。然而，在整个研究过程中，雌激素也被观察到通过独立于细胞内受体调控基因表达的机制影响神经系统功能。直到最近，负责这些快速动作的膜雌激素受体仍然难以捉摸。最近的研究表明，大量这些快速的，膜启动的雌二醇的作用是由于经典雌激素受体的表面表达。本文综述了膜雌激素受体与代谢性谷氨酸受体相互作用对了解雌二醇快速信号传导机制和下游效应的重要性，以及它们在多种生理过程中的意义。
It has been over 60years since the first studies have been published describing the effects of steroid hormones on brain function. For over 30years, estrogen has been presumed to directly affect gene expression and protein synthesis through a specific receptor. More than 20years ago, the first estrogen receptor was cloned and identified as a transcription factor. Yet, throughout their course of study, estrogens have also been observed to affect nervous system function via mechanisms independent of intracellular receptor regulation of gene expression. Up until recently, the membrane estrogen receptors responsible for these rapid actions have remained elusive. Recent studies have demonstrated that a large number of these rapid, membrane-initiated actions of estradiol are due to surface expression of classical estrogen receptors. This review focuses on the importance of membrane estrogen receptor interactions with metabotropic glutamate receptors for understanding rapid estradiol signaling mechanisms and downstream effectors, as well as their significance in a variety of physiological processes.
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影响因子：
5.3
作者：
Dewing, Phoebe;Boulware, Marissa I.;Micevych, Paul
通讯作者：
Micevych, Paul
影响因子：
3.3
作者：
Acconcia, F;Ascenzi, P;Marino, M
通讯作者：
Marino, M
影响因子：
2.5
作者：
Aloisi, AM;Ceccarelli, I;Herdegen, T
通讯作者：
Herdegen, T
影响因子：
7.4
作者：
Amandusson, Å;Hallbeck, M;Blomqvist, A
通讯作者：
Blomqvist, A
影响因子：
3.3
作者：
Chaban, VV;Mayer, EA;Micevych, PE
通讯作者：
Micevych, PE