Regional Deformation of the Optic Nerve Head and Peripapillary Sclera During IOP Elevation.
Regional Deformation of the Optic Nerve Head and Peripapillary Sclera During IOP Elevation.
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DOI：
10.1167/iovs.18-24462
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发表时间：
2018-07-02
影响因子：
4.4
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Pavlatos E;Ma Y;Clayson K;Pan X;Liu J
测量猪视神经乳头（ONH）和视乳头周围巩膜（PPS）对眼内压（IOP）升高的反应。在5 - 30 mm Hg的离体充盈试验期间，使用高频超声对12只猪眼的ONH和PPS进行成像。使用散斑跟踪算法来计算前后方向上的组织位移和巩膜管的扩张。在ONH范围内计算厚度、面内和剪切应变。对区域位移和应变进行了分析比较。ONH和PPS显示对IOP升高的总体后移。在整个充气测试过程中，ONH的后部位移大于PPS的后部位移，并且与PPS的后部位移密切相关。随着IOP的增加，巩膜管扩张比ONH后移位小得多，并且更快地趋于平稳。三层厚度压缩集中在前部ONH，其也经历了比后部ONH更大的平面内应变和剪切应变。在前部ONH内，与中心相比，所有三种应变在周边均显著较高，其中剪切应变在两个区域之间表现出最大的差异。高分辨率超声斑点追踪显示了后眼对IOP升高的全层机械反应。在ONH和PPS之间发现了后移位的不匹配，区域分析显示在前部猪ONH的外周内存在应变集中。这些变形模式可能有助于理解IOP相关的视神经损伤和青光眼易感性。
To measure the deformation of the porcine optic nerve head (ONH) and peripapillary sclera (PPS) in response to intraocular pressure (IOP) elevation. High-frequency ultrasound was used to image the ONH and PPS of 12 porcine eyes during ex vivo inflation testing from 5 to 30 mm Hg. A speckle tracking algorithm was used to compute tissue displacements in the anterior-posterior direction and expansion of the scleral canal. Through-thickness, in-plane, and shear strains were calculated within the ONH. Regional displacements and strains were analyzed and compared. The ONH and PPS showed overall posterior displacement in response to IOP elevation. Posterior displacement of the ONH was larger than and strongly correlated with the posterior displacement of the PPS throughout inflation testing. Scleral canal expansion was much smaller and leveled off quicker than ONH posterior displacement as IOP increased. Through-thickness compression was concentrated in the anterior ONH, which also experienced larger in-plane and shear strains than the posterior ONH. Within the anterior ONH, all three strains were significantly higher in the periphery compared with the center, with the shear strain exhibiting the greatest difference between the two regions. High-resolution ultrasound speckle tracking revealed the full-thickness mechanical response of the posterior eye to IOP elevation. A mismatch in posterior displacement was found between the ONH and PPS, and regional analyses showed a concentration of strains within the periphery of the anterior porcine ONH. These deformation patterns may help in understanding IOP-associated optic nerve damage and glaucoma susceptibility.
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