Association between biomarkers of obesity and risk of high-grade prostatic intraepithelial neoplasia and prostate cancer--evidence of effect modification by prostate size.
Association between biomarkers of obesity and risk of high-grade prostatic intraepithelial neoplasia and prostate cancer--evidence of effect modification by prostate size.
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DOI：
10.1016/j.canlet.2012.10.010
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发表时间：
2013-01-28
期刊：
影响因子：
9.7
通讯作者：
Barocas, Daniel A.
中科院分区：
文献类型：
--
作者：
Fowke, Jay H.;Motley, Saundra;Dai, Qi;Concepcion, Raoul;Barocas, Daniel A.
前列腺肿大常见于衰老和肥胖。我们调查了肥胖与前列腺癌之间的关系，以控制前列腺肥大相关的鉴别检测。在对500名男性的分析中，我们发现身体质量指数、腰臀比和血瘦素水平与高级别PC显著相关，但仅限于没有前列腺肿大的男性。在没有前列腺增大的情况下，瘦素也与高级别前列腺上皮内瘤变（HGPIN）显著相关。我们的研究结果表明，肥胖会促进前列腺癌的发生，前列腺活检的检测偏差可能解释了过去肥胖和前列腺癌之间关系的不一致。
Prostate enlargement is common with aging and obesity. We investigated the association between obesity and prostate cancer controlling for differential detection related to prostate enlargement. In an analysis of 500 men, we found body mass index, waist-hip ratio, and blood leptin levels were significantly associated with high-grade PC, but only among men without prostate enlargement. Leptin was also significantly associated with high-grade prostatic intraepithelial neoplasia (HGPIN) in the absence of prostate enlargement. Our results suggest obesity advances prostate carcinogenesis, and that detection biases at prostate biopsy may explain past inconsistencies in the association between obesity and PC.
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影响因子：
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