Prevalence and distribution of human papillomavirus genotypes among women attending gynecology clinics in northern Henan Province of China.
Prevalence and distribution of human papillomavirus genotypes among women attending gynecology clinics in northern Henan Province of China.
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豫北地区妇科门诊女性人乳头瘤病毒基因型患病率及分布
DOI：
10.1186/s12985-021-01732-8
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发表时间：
2022-01-06
期刊：
影响因子：
4.8
通讯作者：
Zhao L
中科院分区：
文献类型：
--
作者：
Wang X;Song Y;Wei X;Wang G;Sun R;Wang M;Zhao L
研究背景人乳头瘤病毒（HPV）感染可引起宫颈癌和其他癌症，包括外阴癌、阴道癌、阴茎癌、肛门癌和口咽癌。然而，在中国北方的河南省，有关妇科门诊女性HPV患病率和基因型分布的数据有限。本研究旨在调查北方河南省妇科门诊就诊妇女中HPV的流行现状和基因型分布。方法本研究包括2018年1月至2019年12月期间在新乡市中心医院妇科就诊的15，616名年龄在16-81岁之间的妇女。采用常规PCR方法检测HPV DNA，然后进行HPV型特异性杂交，检测17种高危型HPV（HR-HPV）和20种低危型HPV（LR-HPV）。结果北方地区妇女HPV感染率为19.7%，HPV阳性率为10.7%。单、双、多HPV感染分别占13.7%、4.3%、1.8%。以HR-HPV感染为主（71.8%），以单基因型HPV感染为主（13.7%）。最常见的HR-HPV基因型为HPV 16（4.3%），其次为HPV 52（3.5%）和HPV 58（2.0%）。结论北方地区妇科门诊就诊妇女中HPV感染率较高，其中HPV 6型最常见（1.4%），其次为HPV 61型（1.1%）和HPV 81型（1.1%）。20岁以下的妇女发病率最高。在北方河南省，强烈建议9价HPV疫苗进行常规免疫。
BackgroundHuman papillomavirus (HPV) infection can cause cervical and other cancers, including vulva, vagina, penis, anus, or oropharynx. However, in China's northern Henan Province, data on the prevalence and genotype distribution of HPV among women attending gynecology clinics is limited. This study aimed to investigate the current prevalence and genotype distribution of HPV among women attending gynecology clinics in northern Henan Province.MethodsThis study included 15,616 women aged 16–81 years old who visited the Xinxiang central hospital's gynecology department between January 2018 and December 2019. HPV DNA was detected by a conventional PCR method followed by HPV type-specific hybridization, which was designed to detect 17 high-risk HPV (HR-HPV) genotypes and 20 low-risk HPV (LR-HPV) genotypes. HPV prevalence and corresponding 95% confidence intervals (95% CI) were calculated using SPSS 18.0.ResultsThe overall HPV prevalence was 19.7% among women in northern Henan Province. Single, double, and multiple HPV infections accounted for 13.7%, 4.3%, and 1.8% of the total cases. Most infections were caused by HR-HPV (71.8%), and single genotype HPV infection (13.7%) was the most common pattern. The most common HR-HPV genotype was HPV16 (4.3%), followed by HPV52 (3.5%) and HPV58 (2.0%). The most common LR-HPV genotype was HPV6 (1.4%), followed by HPV61 (1.1%) and HPV81 (1.1%).ConclusionsHPV infection is high among women attending gynecology clinics in northern Henan Province. The highest prevalence was found in women less than 20 years old. In northern Henan Province, the 9-valent HPV vaccine is strongly recommended for regular immunization.
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影响因子：
3.7
作者：
Hao, Sijia;Wang, Chunyan;Jiang, Yanfang
通讯作者：
Jiang, Yanfang
影响因子：
3.8
作者：
Bruno, Maria Teresa;Scalia, Guido;Boemi, Sara
通讯作者：
Boemi, Sara
影响因子：
34.3
作者：
Arbyn, Marc;Weiderpass, Elisabete;Bray, Freddie
通讯作者：
Bray, Freddie
DOI：
10.1002/ijgo.13406
发表时间：
2021-01
期刊：
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
影响因子：
--
作者：
Li Y;Wang H;Zhang Y;Jing X;Wu N;Hou Y;Hao C
通讯作者：
Hao C
中国台州地区宫颈人乳头瘤病毒（HPV）基因型流行特征：对37 967名普通人群女性的横断面研究
影响因子：
2.9
作者：
Xu HH;Lin A;Chen YH;Dong SS;Shi WW;Yu JZ;Yan WH
通讯作者：
Yan WH