Correlation between multi-type human papillomavirus infections and viral loads and the cervical pathological grade.
Correlation between multi-type human papillomavirus infections and viral loads and the cervical pathological grade.
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DOI：
10.1002/ijgo.13406
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Hao C
中科院分区：
文献类型：
--
作者：
Li Y;Wang H;Zhang Y;Jing X;Wu N;Hou Y;Hao C
探讨单一/多重HPV感染与宫颈病变的关系，以及病毒载量与宫颈病变程度的相关性。共对27284例接受HPV检测的患者进行了回顾性筛查，并招募了3728名女性，这些女性在2017年5月至2019年3月期间在山西省人民医院进行液基ThinPrep宫颈涂片细胞学检查时检测出HPV阳性，并通过组织病理学诊断。采用荧光定量聚合酶链反应检测HPV基因型和病毒载量。根据病理分级，将宫颈病变分为三组：慢性宫颈炎/宫颈上皮内瘤变（CIN）I; CIN II/CIN III;和宫颈癌。单次和多次HPV感染的分布存在显著的组间差异。HPV 16、18、31、33、51、52、53、58型感染者宫颈组织中病毒载量与宫颈病理分级呈正相关。多型HPV感染比单一型感染更容易加重宫颈病变程度。HPV类型依赖性病毒载量与宫颈病理分级相关。多重HPV感染更易加重宫颈病理分级。HPV病毒载量与宫颈病理分级有关。
To investigate the relationship between single/multiple HPV infections and cervical lesions, and the correlation between viral load and the degree of cervical lesions. A total of 27 284 patients who underwent testing for HPV were retrospectively screened and 3728 women were enrolled who tested positive for HPV when examined by liquid‐based ThinPrep cervical smear cytology test and diagnosed by histopathology at the Shanxi Provincial People's Hospital between May 2017 and March 2019. The genotype and viral load of HPV were determined by fluorescence quantitative polymerase chain reaction. Based on the pathological grade, the cervical lesions were stratified into three groups: chronic cervicitis/cervical intraepithelial neoplasia (CIN) I; CIN II/CIN III; and cervical cancer. There were significant intergroup differences in the distribution of single and multiple HPV infections. There was a positive correlation between the viral load and cervical pathological grade when the infections were caused by HPV 16, 18, 31, 33, 51, 52, 53, and 58. Multi‐type HPV infections are more likely to aggravate the degree of cervical lesions than single‐type infections. The HPV type‐dependent viral load is associated with the cervical pathological grade. Multiple HPV infections are more likely to aggravate the cervical pathological grade. The HPV viral load is type‐dependent with regard to the cervical pathological grade.
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影响因子：
4.7
作者：
Munagala, Radha;Kausar, Hina;Gupta, Ramesh C.
通讯作者：
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影响因子：
8.8
作者：
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DOI：
10.1097/igc.0b013e31829e9fb4
发表时间：
2013-09
期刊：
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
影响因子：
--
作者：
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通讯作者：
Downs LS Jr
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影响因子：
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作者：
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