Analysis of wear, wear particles, and reduced inflammatory potential of vitamin E ultrahigh-molecular-weight polyethylene for use in total joint replacement.
Analysis of wear, wear particles, and reduced inflammatory potential of vitamin E ultrahigh-molecular-weight polyethylene for use in total joint replacement.
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DOI：
10.1002/jbm.b.32904
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发表时间：
2013-04
影响因子：
3.4
通讯作者：
Tipper, J. L.
中科院分区：
文献类型：
--
作者：
Bladen, C. L.;Teramura, S.;Russell, S. L.;Fujiwara, K.;Fisher, J.;Ingham, E.;Tomita, N.;Tipper, J. L.
维生素E（VE）已被添加到超高分子量聚乙烯（UHMWPE）髋臼杯和胫骨托中，主要是为了减少对聚合物的氧化损伤。本研究旨在研究含UHMWPE的VE与原始UHMWPE相比的相对磨损率。还研究了VE减少由刺激的外周血单核细胞（PBMNCs）产生的炎性细胞因子的量的能力。通过将PBMC暴露于脂多糖（LPS）或含VE的UHMWPE（VE-UHMWPE）来实现刺激。在本研究中，结果表明，含或不含VE的UHMWPE的磨损率没有显著差异。含和不含VE的UHMWPE产生的颗粒在粒度分布上没有显著差异。与LPS或VE-UHMWPE颗粒相比，与原始UHMWPE颗粒相比，LPS + VE刺激的（PBMC）中溶骨性介质、肿瘤坏死因子-α、白细胞介素1β（IL-β）、IL-6和IL-8的产生显著减少。当将VE作为液体添加到UHMWPE磨损颗粒刺激的PBMC中时，也观察到了这种趋势。VE如何影响颗粒刺激的巨噬细胞释放炎症介质的确切机制尚不清楚。它可能涉及VE的抗炎和/或抗氧化作用。
Vitamin E (VE) has been added to ultrahigh-molecular-weight polyethylene (UHMWPE) acetabular cups and tibial trays primarily to reduce oxidative damage to the polymer. The aim of this study was to investigate the relative wear rates of UHMWPE-containing VE compared with virgin UHMWPE. The ability of VE to reduce the amount of inflammatory cytokines produced from stimulated peripheral blood mononuclear cells (PBMNCs) was also investigated. Stimulation was achieved by exposure of PBMNCs to either lipoplysaccharide (LPS) or VE-containing UHMWPE (VE-UHMWPE). In the present study, results showed that the wear rates of UHMWPE with or without VE were not significantly different. Particles generated by UHMWPE with and without VE were not significantly different in size distribution. The production of osteolytic mediators, tumor necrosis factor-alpha, interleukin 1β (IL-β), IL-6, and IL-8 were significantly reduced in (PBMNCs) stimulated with either LPS + VE compared with LPS or VE-UHMWPE particles compared to virgin UHMWPE particles. This trend was also observed when VE was added as a liquid to UHMWPE wear particle-stimulated PBMNCs. The exact mechanism of how VE affects the release of inflammatory mediators from particle-stimulated macrophages is not yet understood. It is likely to involve the anti-inflammatory and/or antioxidant effects of VE.
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影响因子：
14
作者：
Shibata, N;Tomita, N
通讯作者：
Tomita, N
影响因子：
14
作者：
Oral, E;Greenbaum, ES;Muratoglu, OK
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Muratoglu, OK
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14
作者：
Oral, E;Wannomae, KK;Muratoglu, OK
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Muratoglu, OK
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作者：
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通讯作者：
Cannas, M
影响因子：
3.5
作者：
Jasty, M;Rubash, HE;Muratoglu, O
通讯作者：
Muratoglu, O