Pancreatic function, type 2 diabetes, and metabolism in aging.
Pancreatic function, type 2 diabetes, and metabolism in aging.
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DOI：
10.1155/2012/320482
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发表时间：
2012
影响因子：
2.8
通讯作者：
Muzumdar RH
中科院分区：
文献类型：
--
作者：
Gong Z;Muzumdar RH
衰老是葡萄糖耐量受损和糖尿病的危险因素。据估计，在2580万美国人中，26.9%的人年龄超过65岁。在某些族裔群体中，这一比例甚至更高;几乎三分之一的西班牙裔和非裔美国人以及四分之三的皮马印第安人老年人患有糖尿病。根据NHANES III（第三次全国健康和营养检查）调查，医生诊断的糖尿病比例从中年人（40-49岁）的3.9%增加到老年人（≥75岁）的13.2%。考虑到糖尿病本身会增加多种其他与年龄相关的疾病（例如癌症、中风、心血管疾病、帕金森病和阿尔茨海默病（AD））的风险，糖尿病的发病率较高尤其令人担忧。本文就衰老对胰岛β细胞功能、胰岛β细胞量、胰岛素分泌和胰岛素敏感性的影响作一综述。我们还回顾了衰老对胰岛素敏感性和胰岛素分泌之间关系的影响。了解导致老年人葡萄糖稳态受损和T2 D的机制将导致开发新的治疗方法，预防或延迟糖尿病，大幅改善生活质量，并最终增加整体寿命。
Aging is a risk factor for impaired glucose tolerance and diabetes. Of the reported 25.8 million Americans estimated to have diabetes, 26.9% are over the age of 65. In certain ethnic groups, the proportion is even higher; almost 1 in 3 older Hispanics and African Americans and 3 out of 4 Pima Indian elders have diabetes. As per the NHANES III (Third National Health and Nutrition Examination) survey, the percentage of physician-diagnosed diabetes increased from 3.9% in middle-aged adults (40–49 years) to 13.2% in elderly adults (≥75 years). The higher incidence of diabetes is especially alarming considering that diabetes in itself increases the risk for multiple other age-related diseases such as cancer, stroke, cardiovascular diseases, Parkinson's disease, and Alzheimer's disease (AD). In this review, we summarize the current evidence on how aging affects pancreatic β cell function, β cell mass, insulin secretion and insulin sensitivity. We also review the effects of aging on the relationship between insulin sensitivity and insulin secretion. Understanding the mechanisms that lead to impaired glucose homeostasis and T2D in the elderly will lead to development of novel treatments that will prevent or delay diabetes, substantially improve quality of life and ultimately increase overall life span.
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影响因子：
6.9
作者：
Alvehus, Malin;Buren, Jonas;Olsson, Tommy
通讯作者：
Olsson, Tommy
影响因子：
16.2
作者：
Cowie, Catherine C.;Engelgau, Michael M.;Gregg, Edward W.
通讯作者：
Gregg, Edward W.
影响因子：
16.2
作者：
Cowie CC;Rust KF;Ford ES;Eberhardt MS;Byrd-Holt DD;Li C;Williams DE;Gregg EW;Bainbridge KE;Saydah SH;Geiss LS
通讯作者：
Geiss LS
影响因子：
7.7
作者：
Carr, DB;Utzschneider, KM;Kahn, SE
通讯作者：
Kahn, SE
影响因子：
8.2
作者：
Baeyens, L;De Breuck, S;Bouwens, L
通讯作者：
Bouwens, L