Long-term exposure to NO2 and PM10 and all-cause and cause-specific mortality in a prospective cohort of women.
Long-term exposure to NO2 and PM10 and all-cause and cause-specific mortality in a prospective cohort of women.
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DOI：
10.1136/oemed-2012-100876
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发表时间：
2013-03
影响因子：
4.9
通讯作者：
Wichmann HE
中科院分区：
文献类型：
--
作者：
Heinrich J;Thiering E;Rzehak P;Krämer U;Hochadel M;Rauchfuss KM;Gehring U;Wichmann HE
我们评估了在颗粒物浓度下降期间，长期暴露于空气污染是否与全因死亡率和特定原因死亡率相关。对来自德国北莱茵-威斯特伐利亚州的约4800名55岁女性进行了长达18年的随访。 通过两种方式评估暴露于空气污染的情况：（1）使用从地理信息系统数据计算的住宅地址与最近的主要道路之间的距离，以及（2）使用从受试者住宅最近的空气监测站数据计算的10 µm以下的颗粒物浓度（PM10）和二氧化氮（NO2）水平的1年平均值。 在整个随访期间，所有受试者中有92%生活在同一社区。使用考克斯比例风险模型（包括混杂因素校正）评估死亡率和暴露之间的关联。16%的妇女在随访期间死亡。PM10（IQR）增加7μg/m3与全因（HR 1.15，95% CI（1.04 - 1.27））、心肺（HR 1.39，95% CI（1.17 - 1.64））和肺癌死亡率（HR 1.84，95% CI（1.23 - 2.74））的HR增加相关。NO2暴露量增加16μg/m3（IQR）与全因（HR 1.18，95% CI（1.07至1.30））和心肺死亡率（HR 1.55，95% CI（1.30至1.84））相关。心肺死亡率和PM10之间的相关性在延长的随访期内降低，在此期间PM10浓度（但不是NO2浓度）较低。居住在主干道附近与全因、心肺和呼吸系统死亡的相对风险增加相关。这些关联在时间上是稳定的。长期暴露于环境PM10和NO2与死亡率增加有关。
We assessed whether long-term exposure to air pollution is associated with all-cause and cause-specific mortality during a period of declining particulate matter concentrations. Approximately 4800 women aged 55 years from North Rhine-Westphalia, Germany, were followed for up to 18 years. Exposure to air pollution was assessed in two ways: (1) using the distance between the residential address and the nearest major road, as calculated from Geographic Information System data and (2) calculating 1-year average particulate matter concentrations below 10 µm (PM10) and nitrogen dioxide (NO2) levels using data from the nearest air-monitoring station data to the subjects’ residences. Ninety-two per cent of all subjects lived in the same community during the entire follow-up period. Associations between mortality and exposure were assessed using Cox's proportional hazards models, including confounder adjustment. Sixteen per cent of women passed away during the follow-up period. An increase of 7 μg/m3 PM10 (IQR) was associated with an increased HR for all-cause (HR 1.15, 95% CI (1.04 to 1.27)), cardiopulmonary (HR 1.39, 95% CI (1.17 to 1.64)), and lung cancer mortality (HR 1.84, 95% CI (1.23 to 2.74)). An increase of 16 μg/m3 (IQR) NO2 exposure was associated with all-cause (HR 1.18, 95% CI (1.07 to 1.30)) and cardiopulmonary mortality (HR 1.55, 95% CI (1.30 to 1.84)). The association between cardiopulmonary mortality and PM10 was reduced for the extended follow-up period, during which PM10 concentrations (but not NO2 concentrations) were lower. Living close to a major road was associated with an increased relative risk for all-cause, cardiopulmonary and respiratory mortality. These associations were temporally stable. Long-term exposure to ambient PM10 and NO2 was associated with increased mortality rates.
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影响因子：
37.8
作者：
Pope, CA;Burnett, RT;Godleski, JJ
通讯作者：
Godleski, JJ
DOI：
10.1080/10473289.2000.10464168
发表时间：
2000-08-01
影响因子：
2.7
作者：
Lipfert, FW;Zhang, J;Wyzga, RE
通讯作者：
Wyzga, RE
影响因子：
5.4
作者：
Beelen, Rob;Hoek, Gerard;Brunekreef, Bert
通讯作者：
Brunekreef, Bert
影响因子：
5.4
作者：
Naess, Oyvind;Piro, Fredrik N.;Leyland, Alastair H.
通讯作者：
Leyland, Alastair H.
影响因子：
168.9
作者：
Hoek, G;Brunekreef, B;van den Brandt, PA
通讯作者：
van den Brandt, PA