Olivary subthreshold oscillations and burst activity revisited.
Olivary subthreshold oscillations and burst activity revisited.
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DOI：
10.3389/fncir.2012.00091
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发表时间：
2012
影响因子：
3.5
通讯作者：
de Jeu MT
中科院分区：
文献类型：
--
作者：
Bazzigaluppi P;De Gruijl JR;van der Giessen RS;Khosrovani S;De Zeeuw CI;de Jeu MT
下橄榄核（IO）是传递信息到小脑皮质的主要通道之一。橄榄神经元处理感觉和运动信号，随后传递到浦肯野细胞。橄榄核神经元的固有阈下膜电位振荡被认为是重要的门控信息流。体外研究表明，阈下振荡的相位决定了橄榄爆发的大小，并可能控制信息流或编码橄榄网络的时间状态。在这里，我们调查是否发生在小鼠橄榄细胞在一个完整的橄榄小脑系统使用在体内全细胞记录技术相同的现象。我们在体内的研究结果表明，橄榄爆发内的小波的数量没有编码的尖峰相对于振荡的相位的时间，但与振荡的振幅。通过应用Harmaline操纵振荡幅度证实了振荡幅度与橄榄爆发内的小波数量之间的反比关系。此外，我们证明了橄榄神经元之间的电紧张耦合影响橄榄爆发大小的调制。基于这些结果，我们认为，橄榄爆发的大小可能反映了“预期”的尖峰发生，而不是尖峰的时间，这个过程需要存在的间隙连接耦合。
The inferior olive (IO) forms one of the major gateways for information that travels to the cerebellar cortex. Olivary neurons process sensory and motor signals that are subsequently relayed to Purkinje cells. The intrinsic subthreshold membrane potential oscillations of the olivary neurons are thought to be important for gating this flow of information. In vitro studies have revealed that the phase of the subthreshold oscillation determines the size of the olivary burst and may gate the information flow or encode the temporal state of the olivary network. Here, we investigated whether the same phenomenon occurred in murine olivary cells in an intact olivocerebellar system using the in vivo whole-cell recording technique. Our in vivo findings revealed that the number of wavelets within the olivary burst did not encode the timing of the spike relative to the phase of the oscillation but was related to the amplitude of the oscillation. Manipulating the oscillation amplitude by applying Harmaline confirmed the inverse relationship between the amplitude of oscillation and the number of wavelets within the olivary burst. Furthermore, we demonstrated that electrotonic coupling between olivary neurons affect this modulation of the olivary burst size. Based on these results, we suggest that the olivary burst size might reflect the “expectancy” of a spike to occur rather than the spike timing, and that this process requires the presence of gap junction coupling.
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影响因子：
5.5
作者：
ANDERSSON, G;ARMSTRONG, DM
通讯作者：
ARMSTRONG, DM
影响因子：
56.9
作者：
CRILL, WE;KENNEDY, TT
通讯作者：
KENNEDY, TT
DOI：
10.1073/pnas.1002995107
发表时间：
2010-06-08
影响因子：
11.1
作者：
Park, Young-Gyun;Park, Hye-Yeon;Kim, Daesoo
通讯作者：
Kim, Daesoo
影响因子：
5.5
作者：
ECCLES, JC;LLINAS, R;SASAKI, K
通讯作者：
SASAKI, K
影响因子：
2.9
作者：
DESCLIN, JC
通讯作者：
DESCLIN, JC