Technical Note: Patient-morphed mesh-type phantoms to support personalized nuclear medicine dosimetry - a proof of concept study.
Technical Note: Patient-morphed mesh-type phantoms to support personalized nuclear medicine dosimetry - a proof of concept study.
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DOI：
10.1002/mp.14784
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发表时间：
2021-04
期刊：
影响因子：
3.8
通讯作者：
Kesner AL
中科院分区：
文献类型：
--
作者：
Carter LM;Camilo Ocampo Ramos J;Bolch WE;Lewis JS;Kesner AL
当前临床放射性核素剂量测定的标准实践使用参考体模，其中定义的器官尺寸代表给定性别和年龄的人口平均值。更大的体模个性化将支持更准确的剂量估计和个性化剂量测定。传统上，裁剪模型是使用操作员密集的解剖图像器官级分割来完成的。现代网格体模提供了增强的解剖真实感，这促使它们集成到蒙特卡洛代码中。在这里，我们提出了一种自动化策略，使用网格参考体模和患者 CT 图像之间基于强度的可变形图像配准来生成患者特定体模/剂量测定。这项工作展示了概念验证的个性化剂量测定工作流程，与手动分割方法进行了比较。通过将 PSRK-Man 参考体模重新采样到体素网格上并使用相应的 Hounsfield 单位 (HU) 参考值定义器官区域，生成线性衰减系数体模。使用 Plastimatch B 样条变形配准将 HU 模型与患者 CT 扫描进行共同配准。同时，手动绘制主要器官的轮廓，以生成“真实的”患者特定模型进行比较。使用这两种方法计算并比较了支持核医学剂量测定的蒙特卡罗得出的 S 值。将派生的 B 样条变换应用于构成 PSRK-Man 的多边形顶点，产生了一个变形变体，该变形变体与患者的身体轮廓和大多数器官体积（通过 Hausdorff 距离和 Dice 度量评估）更加匹配。使用粒子和重离子传输代码系统计算的变形体模的氟 18 的 S 值显示出与源自患者特定模拟的结果更加一致。可变形配准技术可用于创建个性化模型并更好地支持患者特定的剂量测定。该方法被证明比手动分割更容易、更快。我们的研究仅限于概念验证范围，但表明当解剖图像（CT）可用时，可以合理地实现将个性化模型集成到临床剂量测定工作流程中。
Current standard practice for clinical radionuclide dosimetry utilizes reference phantoms, where defined organ dimensions represent population averages for a given sex and age. Greater phantom personalization would support more accurate dose estimations and personalized dosimetry. Tailoring phantoms is traditionally accomplished using operator-intensive organ-level segmentation of anatomic images. Modern mesh phantoms provide enhanced anatomical realism, which has motivated their integration within Monte Carlo codes. Here, we present an automatable strategy for generating patient specific phantoms/dosimetry using intensity-based deformable image registration between mesh reference phantoms and patient CT images. This work demonstrates a proof-of-concept personalized dosimetry workflow, presented in comparison to the manual segmentation approach. A linear attenuation coefficient phantom was generated by resampling the PSRK-Man reference phantom onto a voxel grid and defining organ regions with corresponding Hounsfield unit (HU) reference values. The HU phantom was co-registered with a patient CT scan using Plastimatch B-spline deformable registration. In parallel, major organs were manually contoured to generate a ‘ground truth’ patient-specific phantom for comparisons. Monte Carlo derived S-values, which support nuclear medicine dosimetry, were calculated using both approaches and compared. Application of the derived B-spline transform to the polygon vertices comprising the PSRK-Man yielded a deformed variant more closely matching the patient’s body contour and most organ volumes as-evaluated by Hausdorff distance and Dice metrics. S-values computed for fluorine-18 for the deformed phantom using the Particle and Heavy Ion Transport code System showed improved agreement with those derived from the patient-specific analog. Deformable registration techniques can be used to create a personalized phantom and better support patient-specific dosimetry. This method is shown to be easier and faster than manual segmentation. Our study is limited to a proof-of-concept scope, but demonstrates that integration of personalized phantoms into clinical dosimetry workflows can reasonably be achieved when anatomical images (CT) are available.
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影响因子：
3.5
作者：
Geyer AM;O'Reilly S;Lee C;Long DJ;Bolch WE
通讯作者：
Bolch WE
DOI：
10.1016/j.ejmp.2017.06.003
发表时间：
2017-07-01
影响因子：
3.4
作者：
Zvereva, Alexandra;Schlattl, Helmut;Parodi, Katia
通讯作者：
Parodi, Katia
影响因子：
4.4
作者：
Clark, Kenneth;Vendt, Bruce;Prior, Fred
通讯作者：
Prior, Fred
影响因子：
9.3
作者：
Bolch, Wesley E.;Eckerman, Keith F.;Thomas, Stephen R.
通讯作者：
Thomas, Stephen R.
DOI：
10.1109/jproc.2009.2022417
发表时间：
2009-12
期刊：
Proceedings of the IEEE. Institute of Electrical and Electronics Engineers
影响因子：
--
作者：
Paul Segars W;Tsui BM
通讯作者：
Tsui BM