The UF/NCI family of hybrid computational phantoms representing the current US population of male and female children, adolescents, and adults--application to CT dosimetry.
The UF/NCI family of hybrid computational phantoms representing the current US population of male and female children, adolescents, and adults--application to CT dosimetry.
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DOI：
10.1088/0031-9155/59/18/5225
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发表时间：
2014-09-21
影响因子：
3.5
通讯作者：
Bolch WE
中科院分区：
文献类型：
--
作者：
Geyer AM;O'Reilly S;Lee C;Long DJ;Bolch WE
美国儿童和成人肥胖症的大幅增加促使对当前 UF/NCI（佛罗里达大学/国家癌症研究所）混合计算模型系列进行重大修订，以更准确地反映当前较大身体形态测量的趋势。决定按照身高/体重以网格方式构建新库，而不进一步参考与年龄相关的体重/身高百分位数，因为这些百分位数很快就会过时。在每个身高/体重组合下，定义周向参数并将其用于模型构建。新文库的所有形态测量数据均取自 CDC NHANES 1999 年至 2006 年（最近报告的调查期）期间的调查数据。然后将模型库的一个子集用于 CT 器官剂量敏感性研究，以检查身体形态测量对体重不足至病态肥胖患者的器官剂量大小的影响程度。使用主要和次要形态测量参数，构建了包含 100 个成年男性身高/体重箱、93 个成年女性身高/体重箱、85 个儿童男性身高/体重箱和 73 个儿童女性身高/体重箱的网格。这些网格作为构建包含 351 个计算模型的综合患者模型库的蓝图。在给定的体模站立高度下，儿童男性的标准化 CT 器官剂量随着体模 BMI 的增加而线性下降，而成年女性的器官剂量随着体模 BMI 的增加而呈曲线下降。这些结果表明，体模库的一个非常有用的应用是根据患者剂量跟踪的需要构建用于 CT 成像的预计算剂量库。
Substantial increases in pediatric and adult obesity in the United States have prompted a major revision to the current UF/NCI (University of Florida / National Cancer Institute) family of hybrid computational phantoms to more accurately reflect current trends in larger body morphometry. A decision was made to construct the new library in a gridded fashion by height/weight without further reference to age-dependent weight/height percentiles as these become quickly outdated. At each height/weight combination, circumferential parameters were defined and used for phantom construction. All morphometric data for the new library were taken from the CDC NHANES survey data over the time period 1999 to 2006, the most recent reported survey period. A subset of the phantom library was then used in a CT organ dose sensitivity study to examine the degree to which body morphometry influences the magnitude of organ doses for patients that are underweight to morbidly obese in body size. Using primary and secondary morphometric parameters, grids containing 100 adult male height/weight bins, 93 adult female height/weight bins, 85 pediatric male height/weight bins, and 73 pediatric female height/weight bins were constructed. These grids served as the blueprints for construction of a comprehensive library of patient-dependent phantoms containing 351 computational phantoms. At a given phantom standing height, normalized CT organ doses were shown to linearly decrease with increasing phantom BMI for pediatric males, while curvilinear decreases in organ dose were shown with increasing phantom BMI for adult females. These results suggest that one very useful application of the phantom library would be the construction of a pre-computed dose library for CT imaging as needed for patient dose-tracking.
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影响因子：
3.8
作者：
Segars, W. P.;Bond, Jason;Samei, E.
通讯作者：
Samei, E.
影响因子：
3.5
作者：
Na YH;Zhang B;Zhang J;Caracappa PF;Xu XG
通讯作者：
Xu XG
DOI：
10.1038/oby.2010.248
发表时间：
2011-02
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Camhi SM;Bray GA;Bouchard C;Greenway FL;Johnson WD;Newton RL;Ravussin E;Ryan DH;Smith SR;Katzmarzyk PT
通讯作者：
Katzmarzyk PT
影响因子：
3.5
作者：
Cassola, V. F.;de Melo Lima, V. J.;Khoury, H. J.
通讯作者：
Khoury, H. J.
影响因子：
2.2
作者：
de la Grandmaison, GL;Clairand, I;Durigon, M
通讯作者：
Durigon, M