Metabolic outcomes in very low birthweight and preterm infants in later life.

Metabolic outcomes in very low birthweight and preterm infants in later life.
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极低出生体重和早产儿晚年的代谢结果。

DOI:
10.1016/j.jped.2018.06.002
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发表时间:
2019
影响因子:
3.3
通讯作者:
Embleton ND
Embleton ND
中科院分区:
医学3区
文献类型:
--
作者:
Embleton ND

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在过去的20年里,极低出生体重儿(VLBW)的存活率有了显著提高。这使新生儿护理的目标从单纯关注短期生存转变为考虑早产的终身影响。1新生儿医生当然必须继续加强努力,以减少关键的新生儿发病率,如坏死性小肠结肠炎,败血症和慢性肺病,但现在必须考虑营养和其他干预措施对生命过程的影响。有强有力的数据表明,改善的神经认知结果与较高的早期营养摄入量有关。然而,“健康与疾病的发育起源”(DOHaD)这一新兴学科提高了人们对早期营养摄入量增加和生长速度加快与心血管疾病等长期代谢结果恶化之间关系的认识。
Survival for very low birthweight (VLBW) infants has improved dramatically over the last 2 decades. This has shifted the aim of neonatal care from one that focuses purely on short term survival to one that considers the life-long impacts of preterm birth. 1 Neonatologists must, of course, continue to strengthen their efforts to reduce key neonatal morbidities such as necrotizing enterocolitis, sepsis and chronic lung disease, but must now consider the impact of nutrition and other interventions over the life course. There are strong data to show that improved neurocognitive outcomes are associated with higher early nutrient intakes. However, the emerging discipline of ‘Developmental Origins of Health and Disease’(DOHaD) has increased awareness of the associations between higher nutrient intakes and more rapid growth in early life and worse long-term metabolic outcomes such as cardio-vascular
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