Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor study.
Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor study.
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DOI：
10.1002/jmri.24955
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Waterton JC
中科院分区：
文献类型：
--
作者：
Doblas S;Almeida GS;Blé FX;Garteiser P;Hoff BA;McIntyre DJ;Wachsmuth L;Chenevert TL;Faber C;Griffiths JR;Jacobs AH;Morris DM;O'Connor JP;Robinson SP;Van Beers BE;Waterton JC
评价临床前磁共振成像（MRI）系统中表观扩散系数（ADC）测量值的部位间一致性。设计了一种小型化的热稳定冰水体模。使用七个研究中心的通用协议，在4.7T、7T和9.4T Bruker、Agilent和Magnex小动物MRI系统上测量了几天内的ADC（平均值和四分位距）。日间重复性表示为采集之间平均ADC的变化百分比。交叉位点重现性表示为ADC值偏差百分比的1.96 ×标准差。所有7个部位的ADC测量值均相等，交叉部位ADC重现性为6.3%。ADC测量值的平均日间重复性为2.3%，未发现任何研究中心的测量值与其他研究中心不同（方差分析[ANOVA] P = 0.02，事后检验n.s.）。切片间ADC变异性可忽略不计，并且在不同部位之间相似（P = 0.15）。平均感兴趣区域内ADC变异性为5.5%，其中一个部位的变异性显著大于其他部位（P = 0.0013）。如果采用标准化方案，临床前研究中的绝对ADC值在研究中心和设备之间具有可比性。
To evaluate between-site agreement of apparent diffusion coefficient (ADC) measurements in preclinical magnetic resonance imaging (MRI) systems. A miniaturized thermally stable ice-water phantom was devised. ADC (mean and interquartile range) was measured over several days, on 4.7T, 7T, and 9.4T Bruker, Agilent, and Magnex small-animal MRI systems using a common protocol across seven sites. Day-to-day repeatability was expressed as percent variation of mean ADC between acquisitions. Cross-site reproducibility was expressed as 1.96 × standard deviation of percent deviation of ADC values. ADC measurements were equivalent across all seven sites with a cross-site ADC reproducibility of 6.3%. Mean day-to-day repeatability of ADC measurements was 2.3%, and no site was identified as presenting different measurements than others (analysis of variance [ANOVA] P = 0.02, post-hoc test n.s.). Between-slice ADC variability was negligible and similar between sites (P = 0.15). Mean within-region-of-interest ADC variability was 5.5%, with one site presenting a significantly greater variation than the others (P = 0.0013). Absolute ADC values in preclinical studies are comparable between sites and equipment, provided standardized protocols are employed.
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