Magnetic resonance imaging evaluation of weight-bearing subchondral trabecular bone in the knee.
Magnetic resonance imaging evaluation of weight-bearing subchondral trabecular bone in the knee.
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DOI：
10.1007/s00256-010-0943-z
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发表时间：
2011-01
影响因子：
2.1
通讯作者：
McAlindon, Timothy E.
中科院分区：
文献类型：
--
作者：
Schneider, Erika;Lo, Grace H.;Sloane, Gretchen;Fanella, Lynn;Hunter, David J.;Eaton, Charles B.;McAlindon, Timothy E.
承重软骨下骨的改变是骨关节炎(OA)病理生理学的中心。利用MR，膝关节松质骨通常在轴位平面上被评估，然而部分体积伪影限制了MR方法在分析股骨-胫骨-软骨下骨间室中的应用。斜冠扫描可以直接显示和量化股骨-胫骨软骨下松质骨的预期增加。首先在3特斯拉条件下优化了MR采集参数。此后，五名志愿者接受了右膝的轴位和冠位检查。每个图像系列都进行了直观和定量的评估。在所有包含软骨下骨的冠状切片的胫骨内侧和外侧平台上都放置了一个解剖学上标准化的感兴趣区。测量平均和最大骨髓信号，计算“骨信号”。MR采集的空间分辨率为0.2×0.2×1.0 mm，采集时间为10.5min。2个无症状的膝关节在胫骨软骨下有明显的水平骨小梁，而1个确诊的OA膝关节有软骨下骨的紊乱和水平骨小梁的缺失。膝关节两侧软骨下骨信号比无症状膝关节高8-14%。负重的股骨胫骨软骨下松质骨可在冠状斜面上直观地显示并量化变化。可以使用所得到的图像来执行定性和定量评估，并且可以提供一种区分健康膝部和OA膝部的方法。这些方法应该能够对承重的软骨下骨在膝骨性关节炎的自然历史中的作用进行定量评估。
Changes in weight-bearing subchondral bone are central to osteoarthritis (OA) pathophysiology. Using MR, knee trabecular bone is typically assessed in the axial plane, however partial volume artifacts limit the utility of MR methods for femorotibial compartment subchondral bone analysis. Oblique-coronal acquisitions may enable direct visualization and quantification of the expected increases in femorotibial subchondral trabecular bone. MR acquisition parameters were first optimized at 3 Tesla. Thereafter, five volunteers underwent axial and coronal exams of their right knee. Each image series was evaluated visually and quantitatively. An anatomically standardized region-of-interest was placed on both the medial and lateral tibial plateaus of all coronal slices containing subchondral bone. Mean and maximum marrow signal was measured, and “bone signal” was calculated. The MR acquisition had spatial resolution 0.2× 0.2×1.0 mm and acquisition time 10.5 min. The two asymptomatic knees exhibited prominent horizontal trabeculae in the tibial subchondral bone, while the one confirmed OA knee had disorganized subchondral bone and absent horizontal trabeculae. The subchondral bone signal was 8–14% higher in both compartments of the OA knee than the asymptomatic knees. The weight-bearing femorotibial subchondral trabecular bone can be directly visualized and changes quantified in the coronal-oblique plane. Qualitative and quantitative assessments can be performed using the resultant images and may provide a method to discriminate between the healthy and OA knees. These methods should enable a quantitative evaluation of the role of weight-bearing subchondral bone in the natural history of knee OA to be undertaken.
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影响因子：
27.4
作者：
Hunter, D. J.;Niu, J.;Beals, C. R.
通讯作者：
Beals, C. R.
影响因子：
7
作者：
Lindsey, CT;Narasimhan, A;Majumdar, S
通讯作者：
Majumdar, S
影响因子：
4.2
作者：
Hulet, C;Sabatier, JP;Vielpeau, C
通讯作者：
Vielpeau, C
影响因子：
7
作者：
Blumenkrantz, G;Lindsey, CT;Majumdar, S
通讯作者：
Majumdar, S
影响因子：
7
作者：
Bolbos, R. I.;Zuo, Jin;Majumdar, Sharmila
通讯作者：
Majumdar, Sharmila