Early adverse experience increases emotional reactivity in juvenile rhesus macaques: relation to amygdala volume.
Early adverse experience increases emotional reactivity in juvenile rhesus macaques: relation to amygdala volume.
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DOI：
10.1002/dev.21237
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发表时间：
2014-12
影响因子：
2.2
通讯作者：
Sanchez, Mar M.
中科院分区：
文献类型：
--
作者：
Howell, Brittany R.;Grand, Alison P.;McCormack, Kai M.;Shi, Yundi;LaPrarie, Jamie L.;Maestripieri, Dario;Styner, Martin A.;Sanchez, Mar M.
关键词：
本研究探讨了幼年虐待对幼年恒河猴对新刺激的行为反应的影响及其与杏仁核体积的关系。采用“接近/回避”（AA）和“人类入侵者”（HI）任务，对不同威胁强度的新刺激进行行为反应性测试。体内磁共振成像（MRI）测量杏仁核体积。有趣的是，群体行为差异是情境依赖的。当接触到人类入侵者时，受虐待的受试者表现出比对照组更多的焦虑行为；然而，当受到虐待的动物看到引起恐惧的物体时，它们表现出更强的攻击性，并且检查物体的潜伏期更短。最后，在最低威胁水平（中性新物体）的测试条件下，与对照组相比，受虐待的动物也表现出更短的检查物体的潜伏期，更少的回避和更多的探索。这表明与对照组相比，早期不良经历的动物在威胁评估和行为抑制方面发生了变化。其中一些行为反应与杏仁核体积有关，杏仁核体积与婴儿时期受到虐待的比率呈正相关，尤其是与探索的关系，这与先前的研究一致。
This study investigated the impact of infant maltreatment on juvenile rhesus monkeys’ behavioral reactivity to novel stimuli and its associations with amygdala volume. Behavioral reactivity to novel stimuli of varying threat intensity was measured using Approach/Avoidance (AA) and Human Intruder (HI) tasks. In vivo magnetic resonance imaging (MRI) was used to measure amygdala volume. Interestingly, group behavioral differences were context-dependent. When exposed to a human intruder, maltreated subjects displayed more anxious behaviors than controls; however, when presented with fear-evoking objects, maltreated animals exhibited increased aggression and a shorter latency to inspect the objects. Finally, under testing conditions with the lowest levels of threat (neutral novel objects) maltreated animals also showed shorter latencies to inspect objects, and reduced avoidance and increased exploration compared to controls. This suggests alterations in threat assessment and less behavioral inhibition in animals with early adverse experience compared to controls. Some of these behavioral responses were associated with amygdala volume, which was positively correlated with abuse rates received during infancy, particularly reflecting a relationship with exploration, consistent with previous studies.
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影响因子：
--
作者：
Edmiston, Erin E.;Wang, Fei;Mazure, Carolyn M.;Guiney, Joanne;Sinha, Rajita;Mayes, Linda C.;Blumberg, Hilary P.
通讯作者：
Blumberg, Hilary P.
影响因子：
3.3
作者：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
EHARDT, CL
暴露于父母言语虐待的年轻人中白质异常的初步证据。
影响因子：
10.6
作者：
Choi, Jeewook;Jeong, Bumseok;Rohan, Michael L.;Polcari, Ann M.;Teicher, Martin H.
通讯作者：
Teicher, Martin H.