Auditory processing remains sensitive to environmental experience during adolescence in a rodent model.
Auditory processing remains sensitive to environmental experience during adolescence in a rodent model.
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在啮齿动物模型中，在青春期期间，听觉处理对环境经验仍然很敏感。
DOI：
10.1038/s41467-022-30455-9
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发表时间：
2022-05-24
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
发育过程中神经可塑性的提高有助于感知、运动和认知技能的显着提高。然而，可塑性神经回路很容易受到可能破坏行为成熟的环境影响。虽然这些风险在性成熟之前（即关键时期）就已经确定，但青春期神经脆弱的程度仍然不确定。在这里，我们诱导沙鼠跨越青春期的短暂性听力损失（HL），并询问行为和神经成熟是否受到干扰。通过无线单神经元记录和会话内群体水平分析进行评估，我们发现青少年 HL 会导致显着的知觉缺陷，这可归因于听觉皮层处理能力的退化。最后，青少年 HL 动物的听觉皮层脑切片显示突触缺陷与关键期剥夺后通常观察到的突触缺陷不同。总而言之，这些结果表明，青少年感官体验的减少可能会导致长期的行为缺陷，部分原因是皮质回路功能失调。安布尔等人。将青春期视为感官剥夺的脆弱时期。他们发现，即使是短暂的听觉体验丧失也会导致长期的知觉缺陷，部分原因是皮质处理缺陷。
Elevated neural plasticity during development contributes to dramatic improvements in perceptual, motor, and cognitive skills. However, malleable neural circuits are vulnerable to environmental influences that may disrupt behavioral maturation. While these risks are well-established prior to sexual maturity (i.e., critical periods), the degree of neural vulnerability during adolescence remains uncertain. Here, we induce transient hearing loss (HL) spanning adolescence in gerbils, and ask whether behavioral and neural maturation are disrupted. We find that adolescent HL causes a significant perceptual deficit that can be attributed to degraded auditory cortex processing, as assessed with wireless single neuron recordings and within-session population-level analyses. Finally, auditory cortex brain slices from adolescent HL animals reveal synaptic deficits that are distinct from those typically observed after critical period deprivation. Taken together, these results show that diminished adolescent sensory experience can cause long-lasting behavioral deficits that originate, in part, from a dysfunctional cortical circuit. Anbuhl et al. identify adolescence as a time of vulnerability to sensory deprivation. They find that even a transient loss of auditory experience causes long-lasting perceptual deficits that originate, in part, from a cortical processing deficit.
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影响因子：
3.3
作者：
Eiland, L.;Romeo, R. D.
通讯作者：
Romeo, R. D.
影响因子：
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Banai, Karen;Sabin, Andrew T.;Wright, Beverly A.
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Wright, Beverly A.
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Christakis, D. A.;Ramirez, J. S. B.;Ramirez, J. M.
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Ramirez, J. M.
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Fitzgerald, Matthew B.;Wright, Beverly A.
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Wright, Beverly A.
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CLOPTON, BM;SILVERMAN, MS
通讯作者：
SILVERMAN, MS