Overstimulation of newborn mice leads to behavioral differences and deficits in cognitive performance.
Overstimulation of newborn mice leads to behavioral differences and deficits in cognitive performance.
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DOI：
10.1038/srep00546
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发表时间：
2012
影响因子：
4.6
通讯作者：
Ramirez, J. M.
中科院分区：
文献类型：
--
作者：
Christakis, D. A.;Ramirez, J. S. B.;Ramirez, J. M.
对人类的观察性研究发现，婴儿期过度看电视引起的过度刺激与随后的认知和注意力缺陷之间存在关联。我们开发并测试了一种过度刺激的小鼠模型，其中p10小鼠受到音频（70分贝）和视觉刺激（闪光灯），每天6小时，共42天。 10天后，使用以下测试测试认知和行为：亮暗潜伏期、升高的加迷宫、新物体识别和巴恩斯迷宫。在所有测试中，过度刺激的小鼠表现明显不如对照组，表明活动和冒险增加，短期记忆减少，认知功能下降。这些发现表明，在大脑发育的关键时期过度的非规范性刺激可能对随后的神经认知功能产生明显的不良影响。
Observational studies in humans have found associations between overstimulation in infancy via excessive television viewing and subsequent deficits in cognition and attention. We developed and tested a mouse model of overstimulation whereby p10 mice were subjected to audio (70 db) and visual stimulation (flashing lights) for six hours per day for a total of 42 days. 10 days later cognition and behavior were tested using the following tests: Light Dark Latency, Elevated Plus Maze, Novel Object Recognition, and Barnes Maze. In all tests, overstimulated mice performed significantly worse compared to controls suggesting increased activity and risk taking, diminished short term memory, and decreased cognitive function. These findings suggest that excessive non-normative stimulation during critical periods of brain development can have demonstrable untoward effects on subsequent neurocognitive function.
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