Neuroanatomical circuitry associated with exploratory eye movement in schizophrenia: a voxel-based morphometric study.
Neuroanatomical circuitry associated with exploratory eye movement in schizophrenia: a voxel-based morphometric study.
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与精神分裂症探索性眼运动相关的神经解剖回路：基于体素的形态测量研究
DOI：
10.1371/journal.pone.0025805
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Qiu L;Tian L;Pan C;Zhu R;Liu Q;Yan J;Zhao Q;Yuan H;Han Y;Yue W;Yan H;Zhang D
精神分裂症患者在多种眼球运动任务中表现出异常。探索性眼球运动（EEM）功能障碍似乎是精神分裂症所特有的。然而，精神分裂症 EEM 功能障碍的潜在机制尚不清楚。为了评估 EEM 的潜在神经解剖学基础，我们记录了 EEM 表现，并对 33 名精神分裂症患者和 29 名匹配良好的健康对照者的灰质进行了基于体素的形态测量分析。在精神分裂症患者中，观察到反应搜索得分（RSS）下降和灰质密度（GMD）广泛减少。此外，精神分裂症患者分布脑区的RSS与GMD呈正相关。此外，在精神分裂症患者中，一些具有神经解剖学缺陷的大脑区域与一些与 RSS 相关的区域重叠。这些大脑区域构成了涉及视觉信息处理和眼球运动控制的枕颞额叶回路，包括左侧距状皮层[布罗德曼区（BA）17]、左侧楔叶（BA 18）、左侧枕上皮层（BA 18/19）、左侧额上回（BA 6）、左侧小脑、右侧舌皮层（BA 17/18）、右侧中枕叶皮质 (BA19)、右侧颞下皮质 (BA 37)、右侧背外侧前额皮质 (BA 46) 和双侧中央前回 (BA 6) 延伸至额叶眼区 (FEF, BA 8)。据我们所知，我们首先报告了经验证据，表明视觉处理系统的枕颞额叶神经解剖回路中的灰质损失与精神分裂症中的EEM表现相关，这可能有助于未来揭示精神分裂症中EEM紊乱的潜在神经机制。
Schizophrenic patients present abnormalities in a variety of eye movement tasks. Exploratory eye movement (EEM) dysfunction appears to be particularly specific to schizophrenia. However, the underlying mechanisms of EEM dysfunction in schizophrenia are not clearly understood. To assess the potential neuroanatomical substrates of EEM, we recorded EEM performance and conducted a voxel-based morphometric analysis of gray matter in 33 schizophrenic patients and 29 well matched healthy controls. In schizophrenic patients, decreased responsive search score (RSS) and widespread gray matter density (GMD) reductions were observed. Moreover, the RSS was positively correlated with GMD in distributed brain regions in schizophrenic patients. Furthermore, in schizophrenic patients, some brain regions with neuroanatomical deficits overlapped with some ones associated with RSS. These brain regions constituted an occipito-tempro-frontal circuitry involved in visual information processing and eye movement control, including the left calcarine cortex [Brodmann area (BA) 17], the left cuneus (BA 18), the left superior occipital cortex (BA 18/19), the left superior frontal gyrus (BA 6), the left cerebellum, the right lingual cortex (BA 17/18), the right middle occipital cortex (BA19), the right inferior temporal cortex (BA 37), the right dorsolateral prefrontal cortex (BA 46) and bilateral precentral gyri (BA 6) extending to the frontal eye fields (FEF, BA 8). To our knowledge, we firstly reported empirical evidence that gray matter loss in the occipito-tempro-frontal neuroanatomical circuitry of visual processing system was associated with EEM performance in schizophrenia, which may be helpful for the future effort to reveal the underlying neural mechanisms for EEM disturbances in schizophrenia.
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