Greater reading gain following intervention is associated with low magnetic resonance spectroscopy derived concentrations in the anterior cingulate cortex in children with dyslexia.
Greater reading gain following intervention is associated with low magnetic resonance spectroscopy derived concentrations in the anterior cingulate cortex in children with dyslexia.
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DOI：
10.1016/j.brainres.2021.147386
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发表时间：
2021-05-15
期刊：
影响因子：
2.9
通讯作者：
Horowitz-Kraus T
中科院分区：
文献类型：
--
作者：
Cecil KM;Brunst KJ;Horowitz-Kraus T
“神经噪音”假说表明，患有阅读障碍的个体的谷氨酸浓度高与他们的阅读挑战有关。不同的阅读干预方案显示低GLX（谷氨酰胺和谷氨酸的联合测量，通过体内磁共振波谱获得）与阅读改善有关。几项研究表明，在执行功能（EF）为基础的阅读干预后，阅读能力得到改善，前扣带皮层的激活增加。当前研究的目标有两个：1)确定基于ef的阅读程序的影响是否也延伸到代谢物浓度，特别是前扣带皮层的GLX浓度；2)将阅读障碍的神经噪声假说扩展到支持阅读网络其他部分的神经网络，即与执行功能技能相关的特定区域。患有阅读障碍的儿童和典型的阅读者接受了基于ef的阅读项目的训练。在训练前后评估阅读能力，并在训练结束时获得光谱数据。研究了干预后阅读分数的变化与GLX浓度之间的关系。与典型的阅读者相比，阅读障碍儿童在单词阅读方面的“收益”与低GLX、Glu、Cr和NAA浓度有关。这些结果表明，基于ef的阅读干预方案所报告的改善也涉及低GLX浓度，以及先前与更好的阅读能力相关的额外代谢物（GLX, Cr， NAA），这可能指向神经噪声的降低，特别是在前扣带皮层，这可能是该方案效果的机制。
The “neural noise” hypothesis suggests that individuals with dyslexia have high glutamate concentrations associated with their reading challenges. Different reading intervention programs have showed low GLX (a combined measure for glutamine and glutamate obtained with in vivo magnetic resonance spectroscopy) in association with reading improvement. Several studies demonstrated improved reading and increased activation in the anterior cingulate cortex following an-executive-function (EF)-based reading intervention. The goals of the current study are two-fold: 1) to determine if the effect of the EF-based reading program extends also to the metabolite concentrations and in particular, on the GLX concentrations in the anterior cingulate cortex; 2) to expand the neural noise hypothesis in dyslexia also to neural networks supporting additional parts of the reading networks, i.e. in specific regions related to executive function skills. Children with dyslexia and typical readers were trained on the EF-based reading program. Reading ability was assessed before and after training while spectroscopy data was obtained at the end of the program. The association between change in reading scores following intervention and GLX concentrations was examined. Greater “gains” in word reading were associated with low GLX, Glu, Cr, and NAA concentrations for children with dyslexia compared to typical readers. These results suggest that the improvement reported following the EF-based reading intervention program also involved a low GLX concentration, as well as additional metabolites previously associated with better reading ability (Glx, Cr, NAA) which may point at the decreased neural noise, especially in the anterior cingulate cortex, as a possible mechanism for the effect of this program.
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DOI：
10.1016/j.nicl.2015.06.010
发表时间：
2015
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Horowitz-Kraus T;DiFrancesco M;Kay B;Wang Y;Holland SK
通讯作者：
Holland SK
影响因子：
2.3
作者：
Horowitz-Kraus, Tzipi;Holland, Scott K.
通讯作者：
Holland, Scott K.
影响因子：
4.9
作者：
Breznitz, Z
通讯作者：
Breznitz, Z
影响因子：
16.6
作者：
Breznitz, Zvia;Shaul, Shelley;Karni, Avi
通讯作者：
Karni, Avi
影响因子：
3.1
作者：
Horowitz-Kraus, Tzipi;Vannest, Jennifer J.;Holland, Scott K.
通讯作者：
Holland, Scott K.