Altered functional MR imaging language activation in elderly individuals with cerebral leukoaraiosis.
Altered functional MR imaging language activation in elderly individuals with cerebral leukoaraiosis.
复制标题
患有脑白质疏松症的老年人的功能性磁共振成像语言激活发生改变。
作者：
K. Welker;R. D. De Jesus;R. Watson;M. Machulda;C. Jack
目的
检验脑白质疏松症在语义决策语言任务期间改变功能激活的假设。
材料和方法
经机构审查委员会批准并书面知情同意，18 名右利手、认知健康、脑白质疏松病灶总体积超过 25 cm(3) 的老年参与者和 18 名脑白质疏松病灶小于 5 cm(3) 的年龄匹配对照参与者接受了功能性 MR 成像，以比较语义决策期间的激活与视觉感知决策期间的激活。大脑统计图是从一般线性模型得出的。空间归一化的组 t 图是根据各个对比图像创建的。使用 215 个体素的簇范围阈值来校正多重比较。进行组间随机效应分析。计算每个参与者的语言偏侧性指数。
结果
在对照组参与者中，语义决策激活了双侧视觉皮层、左后下颞叶、左后扣带回、左额叶表达语言区域和左基底神经节。视觉感知决策激活了右顶叶和后颞叶。患有脑白质疏松症的参与者在与语义决策相关的所有区域中都表现出激活减少；然而，与视觉感知决策相关的激活程度有所增加。组间分析显示白质疏松症参与者的左前枕叶 (P=.016)、右后颞叶 (P=.048) 和右基底神经节 (P=.009) 的激活显着减少。在脑白质疏松症组中，个体参与者的偏侧性指数显示出强烈的左偏性趋势（P=0.059）。
结论
中度脑白质疏松症与语义决策任务期间的非典型功能激活有关。因此，脑白质疏松症是老年人功能性磁共振成像研究中的一个重要混杂变量。
PURPOSE
To test the hypothesis that leukoaraiosis alters functional activation during a semantic decision language task.
MATERIALS AND METHODS
With institutional review board approval and written informed consent, 18 right-handed, cognitively healthy elderly participants with an aggregate leukoaraiosis lesion volume of more than 25 cm(3) and 18 age-matched control participants with less than 5 cm(3) of leukoaraiosis underwent functional MR imaging to allow comparison of activation during semantic decisions with that during visual perceptual decisions. Brain statistical maps were derived from the general linear model. Spatially normalized group t maps were created from individual contrast images. A cluster extent threshold of 215 voxels was used to correct for multiple comparisons. Intergroup random effects analysis was performed. Language laterality indexes were calculated for each participant.
RESULTS
In control participants, semantic decisions activated the bilateral visual cortex, left posteroinferior temporal lobe, left posterior cingulate gyrus, left frontal lobe expressive language regions, and left basal ganglia. Visual perceptual decisions activated the right parietal and posterior temporal lobes. Participants with leukoaraiosis showed reduced activation in all regions associated with semantic decisions; however, activation associated with visual perceptual decisions increased in extent. Intergroup analysis showed significant activation decreases in the left anterior occipital lobe (P=.016), right posterior temporal lobe (P=.048), and right basal ganglia (P=.009) in particpants with leukoariosis. Individual participant laterality indexes showed a strong trend (P=.059) toward greater left lateralization in the leukoaraiosis group.
CONCLUSION
Moderate leukoaraiosis is associated with atypical functional activation during semantic decision tasks. Consequently, leukoaraiosis is an important confounding variable in functional MR imaging studies of elderly individuals.
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
M. Just;T. Keller;N. Minshew;V. Cherkassky
通讯作者：
M. Just;T. Keller;N. Minshew;V. Cherkassky
影响因子：
14.5
作者：
Frost, JA;Binder, JR;Cox, RW
通讯作者：
Cox, RW
影响因子：
9.9
作者：
Smith, CD;Andersen, AH;Avison, MJ
通讯作者：
Avison, MJ
影响因子：
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作者：
Kantarci, Kejal;Petersen, Ronald C.;Przybelski, Scott A.;Weigand, Stephen D.;Shiung, Maria M.;Whitwell, Jennifer L.;Negash, Selamawit;Ivnik, Robert J.;Boeve, Bradley F.;Knopman, David S.;Smith, Glenn E.;Jack, Clifford R., Jr.
通讯作者：
Jack, Clifford R., Jr.