Validation of a brain MRI relaxometry protocol to measure effects of preterm birth at a flexible postnatal age.
Validation of a brain MRI relaxometry protocol to measure effects of preterm birth at a flexible postnatal age.
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DOI：
10.1186/1471-2431-14-84
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发表时间：
2014-03-28
期刊：
影响因子：
2.4
通讯作者：
Anderson AW
中科院分区：
文献类型：
--
作者：
Maitre NL;Slaughter JC;Stark AR;Aschner JL;Anderson AW
磁共振成像（MRI）是一个有用的工具，研究早产儿的大脑生长和组织的临床和研究目的，但其实用性可能受到时间和医疗条件的限制。本研究的目的是确定MRI弛豫测量的深核，而不是白色物质，将反映出生时的胎龄对运动发育必不可少的结构的影响，无论出生后的年龄在成像时。这是一项前瞻性观察性研究，研究对象为在范德比尔特新生儿重症监护室（NICU）接受常规神经影像学检查无脑损伤的婴儿。在月经后足月年龄的2个月窗口内使用MRI弛豫测量法对婴儿进行研究。在45名婴儿中，白色物质MRI T1弛豫时间受成像时胎龄和出生后年龄的影响（胎龄的R2 = 0.19 vs.校正胎龄和成像时年龄的R2 = 0.34;所有p < 0.01）。用T2弛豫时间获得了类似的结果。相比之下，苍白球T1反映了胎龄，但受出生后年龄的影响最小（R2 = 0.50 vs. 0.57，p < 0.001）。使用该成像方案获得的结果与苍白球的缓慢成熟是一致的，苍白球是复杂运动程序正常发育到成年期所必需的。苍白球MRI弛豫测量出生时胎龄对早产儿脑发育的影响，独立于出生后年龄，并应被证明是有用的预测建模在一个灵活的时间窗口，月经后期的任期。
Magnetic resonance imaging (MRI) is a useful tool to study brain growth and organization in preterm neonates for clinical and research purposes, but its practicality can be limited by time and medical constraints. The aim of this study was to determine if MRI relaxometry of the deep nuclei, as opposed to white matter, would reflect the influence of gestational age at birth on structures essential to motor development, regardless of postnatal age at the time of imaging. This was a prospective observational study of infants without brain injury on conventional neuroimaging who were cared for in the neonatal intensive care unit (NICU) at Vanderbilt. Infants were studied using MRI relaxometry within a 2-month window of postmenstrual term age. In 45 infants, white matter MRI T1 relaxation times were influenced by both gestational age and postnatal age at imaging time (R2 = 0.19 for gestational age vs. R2 = 0.34 adjusting for both gestational age and age at imaging; all p < 0.01). Similar results were obtained with T2 relaxation times. In contrast, globus pallidus T1 reflected gestational age but was minimally affected by postnatal age (R2 = 0.50 vs. 0.57, p < 0.001). The results obtained using this imaging protocol are consistent with the slow maturation of the globus pallidus, essential to normal development of complex motor programs into adulthood. Globus pallidus MRI relaxometry measures the impact of gestational age at birth on brain development independent of postnatal age in preterm infants and should prove useful for predictive modeling in a flexible time-window around postmenstrual term age.
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影响因子：
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