Entorhinal grid-like codes and time-locked network dynamics track others navigating through space.
Entorhinal grid-like codes and time-locked network dynamics track others navigating through space.
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DOI：
10.1038/s41467-023-35819-3
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发表时间：
2023-01-31
影响因子：
16.6
通讯作者：
Lamm, Claus
中科院分区：
文献类型：
--
作者：
Wagner, Isabella C.;Graichen, Luise P.;Todorova, Boryana;Luettig, Andre;Omer, David B.;Stangl, Matthias;Lamm, Claus
在拥挤、动态变化的环境中导航需要跟踪其他个体的能力。内嗅皮层的网格细胞是自我导航的核心组成部分，但它们是否也跟踪他人的运动尚不清楚。在这里，我们建议内嗅网格状代码的社会空间导航作出重要贡献。60名人类参与者接受了功能性磁共振成像（fMRI），同时观察和重新追踪导航虚拟现实环境的演示者的不同路径。结果显示，内嗅皮层中的网格状代码跟踪其他个体在空间中的导航。网格状代码的活动被时间锁定在共激活和内鼻皮层连接的增加，包括纹状体，海马，海马旁和右后顶叶皮层。令人惊讶的是，在观察过程中的网格相关的影响更强的参与者表现得更差时，随后重新跟踪示威者的路径。我们的研究结果表明，与内嗅网格细胞相关活动时间锁定的网络动态可能有助于在整个大脑中分发有关他人位置的信息。在日常环境中导航需要跟踪他人的能力。在这里，作者表明这种能力与人类内嗅皮质中的网格状代码有关，这些代码发出其他人所走空间路径的信号。
Navigating through crowded, dynamically changing environments requires the ability to keep track of other individuals. Grid cells in the entorhinal cortex are a central component of self-related navigation but whether they also track others’ movement is unclear. Here, we propose that entorhinal grid-like codes make an essential contribution to socio-spatial navigation. Sixty human participants underwent functional magnetic resonance imaging (fMRI) while observing and re-tracing different paths of a demonstrator that navigated a virtual reality environment. Results revealed that grid-like codes in the entorhinal cortex tracked the other individual navigating through space. The activity of grid-like codes was time-locked to increases in co-activation and entorhinal-cortical connectivity that included the striatum, the hippocampus, parahippocampal and right posterior parietal cortices. Surprisingly, the grid-related effects during observation were stronger the worse participants performed when subsequently re-tracing the demonstrator’s paths. Our findings suggests that network dynamics time-locked to entorhinal grid-cell-related activity might serve to distribute information about the location of others throughout the brain. Navigating through everyday environments requires the ability to keep track of others. Here, the authors show this ability is linked to grid-like codes in the human entorhinal cortex that signal the spatial paths other individuals take.
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DOI：
10.1126/science.abg1278
发表时间：
2021-07-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dotson NM;Yartsev MM
通讯作者：
Yartsev MM
影响因子：
19.9
作者：
Epstein, Russell A.
通讯作者：
Epstein, Russell A.
影响因子：
64.8
作者：
Epstein, R;Kanwisher, N
通讯作者：
Kanwisher, N
影响因子：
5.7
作者：
Daselaar, SM;Prince, SE;Cabeza, R
通讯作者：
Cabeza, R
DOI：
10.1098/rstb.2015.0355
发表时间：
2016-10-05
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Barron HC;Garvert MM;Behrens TE
通讯作者：
Behrens TE