Nonlocal spatiotemporal representation in the hippocampus of freely flying bats.

Nonlocal spatiotemporal representation in the hippocampus of freely flying bats.
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DOI:
10.1126/science.abg1278
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发表时间:
2021-07-09
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Yartsev MM
Yartsev MM
中科院分区:
其他
文献类型:
--
作者:
Dotson NM;Yartsev MM

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导航发生在空间和时间的连续体中。众所周知,海马体对运动动物的即时位置进行编码。然而,主动导航,特别是在高速下,可能需要表示超越当前时刻的导航信息。利用自由飞行蝙蝠的无线电生理记录,我们证明了CA1区域的神经活动主要编码离蝙蝠当前位置几米远的非局部空间信息。这种时空表征在时间上向前和向后延伸,强调未来的位置,并在随机探索和目标导向的导航中发现。因此,位置的表征沿着一个连续体延伸,每个时刻都包含有关过去、现在和未来的信息,并可能为沿着自我选择和记忆的路径导航提供关键机制。
Navigation occurs through a continuum of space and time. The hippocampus is known to encode the immediate position of moving animals. However, active navigation, especially at high speeds, may require representing navigational information beyond the present moment. Using wireless electrophysiological recordings in freely flying bats, we demonstrate that neural activity in area CA1 predominantly encodes nonlocal spatial information up to meters away from the bat’s present position. This spatiotemporal representation extends both forward and backward in time, with an emphasis on future locations, and is found during both random exploration and goal-directed navigation. The representation of position thus extends along a continuum, with each moment containing information about past, present, and future, and may provide a key mechanism for navigating along self-selected and remembered paths.
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