Stem cell therapies for periodontal tissue regeneration: a network meta-analysis of preclinical studies.
Stem cell therapies for periodontal tissue regeneration: a network meta-analysis of preclinical studies.
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牙周组织再生的干细胞疗法：临床前研究的网络荟萃分析。
DOI：
10.1186/s13287-020-01938-7
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发表时间：
2020-10-02
影响因子：
7.5
通讯作者：
Mou Y
中科院分区：
文献类型：
--
作者：
Li Q;Yang G;Li J;Ding M;Zhou N;Dong H;Mou Y
牙周组织再生（PTR）是牙周治疗的最终目标。目前，干细胞疗法被认为是实现 PTR 的有前途的策略。然而，仍然没有结论性的比较来区分不同种类干细胞之间的明确层次结构。截至 2020 年 2 月，使用 MEDLINE（通过 PubMed）、EMBASE 和 Web of Science 进行了系统回顾和网络荟萃分析 (NMA)。其中包括评估五种干细胞 PTR 的临床前研究；这五种干细胞包括牙周膜来源干细胞（PDLSC）、骨髓来源干细胞（BMSC）、脂肪组织来源干细胞（ADSC）、牙髓来源干细胞（DPSC）和牙龈来源干细胞（GMSC）。主要结果是具有连续变量的三个组织学指标：新形成的牙槽骨（NB）、新形成的牙骨质（NC）和新形成的牙周膜（NPDL）。我们使用随机效应模型进行成对荟萃分析，然后使用多元荟萃分析模型进行随机效应 NMA。确定了六十项评估五种不同干细胞疗法的临床前研究。 NMA显示，就NB而言，PDLSC（标准化平均差1.87，95%可信区间1.24至2.51）、BMSC（1.88、1.17至2.59）和DPSC（1.69、0.64至2.75）在统计上比细胞载体（CC）更有效。此外，PDLSC 优于 GMSC（1.49、0.04 至 2.94）。对于NC，PDLSC（2.18、1.48至2.87）、BMSC（2.11、1.28至2.94）和ADSC（1.55、0.18至2.91）优于CC。对于 NPDL，PDLSC（1.69、0.92 至 2.47）和 BMSC（1.41、0.56 至 2.26）比 CC 更有效，PDLSC（1.26、0.11 至 2.42）优于 GMSC。治疗等级的结果还表明，排名最高的两种干预措施是 PDLSC 和 BMSC。在本研究评估的五种干细胞中，PDLSC和BMSC是PTR最有效且记录最充分的干细胞，并且它们之间没有统计学意义。为了将 PTR 干细胞疗法成功应用于临床，未来的研究应利用可靠的实验设计和报告。
Periodontal tissue regeneration (PTR) is the ultimate goal of periodontal therapy. Currently, stem cell therapy is considered a promising strategy for achieving PTR. However, there is still no conclusive comparison that distinguishes clear hierarchies among different kinds of stem cells. A systematic review and network meta-analysis (NMA) was performed using MEDLINE (via PubMed), EMBASE, and Web of Science up to February 2020. Preclinical studies assessing five types of stem cells for PTR were included; the five types of stem cells included periodontal ligament-derived stem cells (PDLSCs), bone marrow-derived stem cells (BMSCs), adipose tissue-derived stem cells (ADSCs), dental pulp-derived stem cells (DPSCs), and gingival-derived stem cells (GMSCs). The primary outcomes were three histological indicators with continuous variables: newly formed alveolar bone (NB), newly formed cementum (NC), and newly formed periodontal ligament (NPDL). We performed pairwise meta-analyses using a random-effects model and then performed a random-effects NMA using a multivariate meta-analysis model. Sixty preclinical studies assessing five different stem cell-based therapies were identified. The NMA showed that in terms of NB, PDLSCs (standardized mean difference 1.87, 95% credible interval 1.24 to 2.51), BMSCs (1.88, 1.17 to 2.59), and DPSCs (1.69, 0.64 to 2.75) were statistically more efficacious than cell carriers (CCs). In addition, PDLSCs were superior to GMSCs (1.49, 0.04 to 2.94). For NC, PDLSCs (2.18, 1.48 to 2.87), BMSCs (2.11, 1.28 to 2.94), and ADSCs (1.55, 0.18 to 2.91) were superior to CCs. For NPDL, PDLSCs (1.69, 0.92 to 2.47) and BMSCs (1.41, 0.56 to 2.26) were more efficacious than CCs, and PDLSCs (1.26, 0.11 to 2.42) were superior to GMSCs. The results of treatment hierarchies also demonstrated that the two highest-ranked interventions were PDLSCs and BMSCs. PDLSCs and BMSCs were the most effective and well-documented stem cells for PTR among the five kinds of stem cells evaluated in this study, and there was no statistical significance between them. To translate the stem cell therapies for PTR successfully in the clinic, future studies should utilize robust experimental designs and reports.
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影响因子：
7.5
作者：
Cao Y;Liu Z;Xie Y;Hu J;Wang H;Fan Z;Zhang C;Wang J;Wu CT;Wang S
通讯作者：
Wang S
影响因子：
--
作者：
Dogan, A;Özdemir, A;Oygür, T
通讯作者：
Oygür, T
影响因子：
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作者：
Dogan, A;Özdemir, A;Oygür, T
通讯作者：
Oygür, T
影响因子：
4.6
作者：
Chien KH;Chang YL;Wang ML;Chuang JH;Yang YC;Tai MC;Wang CY;Liu YY;Li HY;Chen JT;Kao SY;Chen HL;Lo WL
通讯作者：
Lo WL
影响因子：
--
作者：
Amghar-Maach, Sara;Gay-Escoda, Cosme;Sanchez-Garces, M Angeles
通讯作者：
Sanchez-Garces, M Angeles