Anterior cingulate cortex supports effort allocation towards a qualitatively preferred option.
Anterior cingulate cortex supports effort allocation towards a qualitatively preferred option.
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DOI：
10.1111/ejn.13608
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Izquierdo A
中科院分区：
文献类型：
--
作者：
Hart EE;Gerson JO;Zoken Y;Garcia M;Izquierdo A
前扣带皮层（ACC）是已知的，参与努力的选择，但其在质量上不同的奖励（更多/更少的首选），超越幅度差异（更大/更小）的成本效益评估的作用，是知之甚少。在性质不同的选项之间进行选择是人类通常面临的决策类型。在这里，我们评估了ACC的任务，主要是用来探测纹状体功能的动机的作用。大鼠进行训练，以稳定的性能上的一个渐进的比例时间表的蔗糖丸，然后给予假手术（对照）或兴奋性毒性NMDA病变ACC. Accordingly，一个选择被引入：食物是同时可用的，而动物可以工作的首选蔗糖丸。ACC病变产生了显着减少杠杆压力蔗糖颗粒相比，控制，而食物的消费量不受影响。病变没有影响蔗糖丸的偏好时，这两种选择都是免费的。当实验室食物不能同时提供时，ACC损伤大鼠表现出与对照组相似的杠杆按压。在特定饱腹感的蔗糖颗粒的测试中，ACC损伤的大鼠也表现出完整的贬值效应。在我们的任务中，ACC病变的影响不是由食欲下降、食物偏好改变、无法更新价值观或学习缺陷介导的。综上所述，我们发现ACC病变减少了定性首选选项的努力。这些结果进行了讨论，参考纹状体操作的影响，我们最近的报告基底外侧杏仁核的作用，在努力的选择。
The anterior cingulate cortex (ACC) is known to be involved in effortful choice, yet its role in cost-benefit evaluation of qualitatively different rewards (more/less preferred), beyond magnitude differences (larger/smaller), is poorly understood. Selecting between qualitatively different options is a decision type commonly faced by humans. Here, we assessed the role of ACC on a task that has primarily been used to probe striatal function in motivation. Rats were trained to stable performance on a progressive ratio schedule for sucrose pellets and were then given sham surgeries (control) or excitotoxic NMDA lesions of ACC. Subsequently, a choice was introduced: chow was concurrently available while animals could work for the preferred sucrose pellets. ACC lesions produced a significant decrease in lever presses for sucrose pellets compared to control, whereas chow consumption was unaffected. Lesions had no effect on sucrose pellet preference when both options were freely available. When laboratory chow was not concurrently available, ACC-lesioned rats exhibited similar lever pressing as controls. During a test under specific satiety for sucrose pellets, ACC-lesioned rats also showed intact devaluation effects. The effects of ACC lesions in our task are not mediated by decreased appetite, a change in food preference, a failure to update value or a learning deficit. Taken together, we found that ACC lesions decreased effort for a qualitatively preferred option. These results are discussed with reference to effects of striatal manipulations and our recent report of a role for basolateral amygdala in effortful choice.
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