Surgically Induced Focal Retinal Detachment Does Not Cause Detectable SD-OCT Retinal Changes in Normal Human Retina.
Surgically Induced Focal Retinal Detachment Does Not Cause Detectable SD-OCT Retinal Changes in Normal Human Retina.
复制标题
DOI：
10.1167/iovs.17-22737
复制
发表时间：
2017-10-01
影响因子：
4.4
通讯作者：
Kashani AH
中科院分区：
文献类型：
--
作者：
Kogachi K;Wolfe JD;Kashani AH
诱导局灶性视网膜脱离（RD）的视网膜下输送干细胞和基因治疗越来越普遍。为了确定该手术是否对视网膜有不良影响，我们使用光谱域光学相干断层扫描（SD-OCT）来评估手术置换过程中偶然脱离的正常视网膜周围的大黄斑下出血（SMH）的术前和术后视网膜解剖。通过临床检查、眼底摄影和SD-OCT，对单眼SMH患者在手术移位前后进行回顾性观察研究。在涉及SMH和周围正常视网膜的区域进行人工测量视网膜内厚度（IRT），视网膜外厚度（ORT）和全视网膜厚度（FRT）。视网膜厚度测量值的比较采用Wilcoxon符号秩检验。本研究包括7只眼睛。所有眼均成功行SMH移位手术。6/7名受试者的视力得到改善，其余受试者的视力没有变化。SMH周围正常视网膜区域的偶然RD不会引起SD-OCT检测到的IRT、ORT或FRT的任何显著变化。相比之下，与SMH移位或正常相邻视网膜相比，术前SMH覆盖的平均FRT面积显著增加。手术诱导的局灶性RD在大SMH周围偶然脱离的正常视网膜中不会引起可检测的视网膜改变。因此，手术诱导局灶性RD不应被认为与病理性RD对视网膜有相同的不良影响。
Induction of focal retinal detachment (RD) for subretinal delivery of stem cells and gene therapy is increasingly common. In order to determine if this procedure has an adverse impact on the retina, we use spectral-domain optical coherence tomography (SD-OCT) to evaluate the pre- and postoperative retinal anatomy of the incidentally detached normal retina surrounding large submacular hemorrhages (SMH) during surgical displacement procedures. Retrospective, observational study of human subjects with monocular SMH evaluated before and after surgical displacement using clinical exam, fundus photography, and SD-OCT. Manual measurements of the inner retinal thickness (IRT), outer retinal thickness (ORT), and full retinal thickness (FRT) were made in regions involving the SMH and surrounding normal retina. Comparison of retinal thickness measurements was made using the Wilcoxon signed-rank test. Seven eyes were included in this study. All eyes successfully underwent surgical displacement of SMH. Visual acuity improved in 6/7 subjects and was unchanged in the remaining subject. Incidental RD of the normal retinal regions surrounding the SMH did not cause any significant change in IRT, ORT, or FRT that was detectable by SD-OCT. In contrast, mean FRT overlying regions with SMH was significantly greater before surgery compared to after displacement of SMH or normal adjacent retina. Surgically induced focal RD does not cause detectable retinal changes in the incidentally detached normal retina surrounding large SMH. Therefore, surgical induction of focal RD should not be considered to have the same adverse impact on the retina as pathologic RD.
登录
查看更多内容
影响因子：
--
作者：
Jacobson, Samuel G.;Cideciyan, Artur V.;Ratnakaram, Ramakrishna;Heon, Elise;Schwartz, Sharon B.;Roman, Alejandro J.;Peden, Marc C.;Aleman, Tomas S.;Boye, Sanford L.;Sumaroka, Alexander;Conlon, Thomas J.;Calcedo, Roberto;Pang, Ji-Jing;Erger, Kirsten E.;Olivares, Melani B.;Mullins, Cristina L.;Swider, Malgorzata;Kaushal, Shalesh;Feuer, William J.;Iannaccone, Alessandro;Fishman, Gerald A.;Stone, Edwin M.;Byrne, Barry J.;Hauswirth, William W.
通讯作者：
Hauswirth, William W.
影响因子：
4.2
作者：
Arroyo, JG;Yang, L;Chen, DF
通讯作者：
Chen, DF
影响因子：
4.2
作者：
GLATT, H;MACHEMER, R
通讯作者：
MACHEMER, R
DOI：
10.1097/iae.0b013e3182180114
发表时间：
2012-01-01
影响因子：
3.3
作者：
Gharbiya, Magda;Grandinetti, Francesca;Gabrieli, Corrado Balacco
通讯作者：
Gabrieli, Corrado Balacco
影响因子：
13.7
作者：
Schocket, LS;Witkin, AJ;Duker, JS
通讯作者：
Duker, JS