Effects of chronic ethanol consumption on cytokine regulation of liver regeneration.
Effects of chronic ethanol consumption on cytokine regulation of liver regeneration.
复制标题
慢性乙醇消耗对肝再生细胞因子调节的影响。
DOI：
10.1152/ajpgi.1998.275.4.g696
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Diehl,AM
中科院分区：
文献类型：
--
作者：
Yang,SQ;Lin,HZ;Yin,M;Albrecht,JH;Diehl,AM
Ethanol ingestion may interrupt the proregenerative signal transduction that is initiated by injury-related cytokines such as tumor necrosis factor (TNF)-α and TNF-α- inducible cytokines including interleukin (IL)-6. To test this theory, liver regeneration, TNF-α and IL-6 expression, and cytokine-regulated prereplicative events were compared in ethanol-fed rats and isocalorically fed controls after 70% partial hepatectomy (PH). Ethanol feeding inhibits hepatocyte replication and recovery of liver mass after PH but generally promotes induction of both cytokines in the liver and extrahepatic tissues (i.e., white adipose tissue). Cytokine-regulated events that occur early in the prereplicative period are influenced differentially. TNF-α-dependent increases in hepatic nuclear factor-κB (NF-κB) p50 and p65 expression and DNA binding activity are prevented, whereas IL-6-dependent inductions of hepatic Stat-3 phosphorylation and DNA binding activity occur normally. In contrast, events (e.g., induction of cyclin D1, cdk-1, cyclin D3, and p53 mRNA) that occur at the end of the prereplicative period are uniformly inhibited. These findings indicate that chronic ethanol ingestion arrests the regenerative process during the prereplicative period and demonstrate that increased TNF-α, IL-6 and Stat-3 are not sufficient to assure hepatocyte proliferation after PH.
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影响因子：
56.9
作者：
YU, CL;MEYER, DJ;JOVE, R
通讯作者：
JOVE, R
原代大鼠肝细胞在生长周期和转化生长因子-α 诱导的有丝分裂转变期间表达细胞周期蛋白 D1 信使 RNA。
影响因子：
3.1
作者：
Koch,KS;Lu,XP;Leffert,HL
通讯作者：
Leffert,HL
DOI：
--
发表时间：
1979
期刊：
Journal of Laboratory and Clinical Medicine
影响因子：
--
作者：
W. Frank;A. Rayyes;A. Washington;P. Holt
通讯作者：
P. Holt
DOI：
10.1152/ajpgi.1996.270.6.g909
发表时间：
1996-06-01
影响因子：
4.5
作者：
Rai, RM;Yang, SQ;Diehl, AM
通讯作者：
Diehl, AM
影响因子：
13.5
作者：
DIEHL, AM;CHACON, M;WAGNER, P
通讯作者：
WAGNER, P