The effect of cavernous nerve traction on erectile function in rats.
The effect of cavernous nerve traction on erectile function in rats.
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海绵神经牵引对大鼠勃起功能的影响
DOI：
10.1371/journal.pone.0186077
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Li H;Chen L;Wang T;Wang S;Liu J
我们进行了这项研究，以评估海绵体神经（CN）牵引对大鼠勃起功能的影响。将32只8周龄SD大鼠分为4组：对照组、CN牵引1 min组、CN牵引2 min组和CN挤压2 min组。使用玻璃钩以0.2牛顿的拉力进行CN牵引。一个月后，测量对CN刺激的平均动脉压（MAP）和海绵体内压（ICP）以评估勃起功能。取阴茎和盆大神经节（MPG），观察神经元型一氧化氮合酶（nNOS）和神经丝的表达、纤维化和细胞凋亡。CN牵引2 min组ICP/MAP比值较对照组降低（P < 0.05）。CN挤压组的ICP/MAP比值低于其他三组（P < 0.05）。CN牵引组MPG和阴茎背神经nNOS表达低于对照组，但高于CN挤压组（P < 0.05）。CN牵引2 min后，阴茎背神经内神经纤维数减少（P < 0.05）。CN牵拉2 min组胶原/平滑肌比值及细胞凋亡均较对照组增加（P < 0.05）。结果表明，CN牵引是一种有效的CN损伤模型，与CN挤压模型相比，它造成的损伤相对较轻。
We performed this study to evaluate the effect of cavernous nerve (CN) traction on erectile function in rats. Thirty-two 8- week-old Sprague–Dawley rats were divided into four groups: control, 1-minute CN traction, 2-minute CN traction, and 2-minute CN crush. CN traction was performed using a glass hook with a tensile force of 0.2 Newton. One month later, the mean arterial pressure (MAP) and intracavernosal pressure (ICP) in response to CN stimulation were measured to assess erectile function. The penis and major pelvic ganglion (MPG) were harvested to explore the expression of neuronal nitric oxide synthase (nNOS) and neurofilament, fibrosis and apoptosis. The ICP/MAP ratio was reduced in the 2-minute CN traction group compared with the control group (P < 0.05). The ICP/MAP ratio in the CN crush group was lower than in the other three groups (P < 0.05, for each). Expression of nNOS in both MPG and dorsal penile nerve was lower in the CN traction group than in the control group, but was higher than in the CN crush group (P < 0.05). Nerve fiber number in the dorsal penile nerve was reduced by 2-minute CN traction (P < 0.05). The ratios of collagen to smooth muscle content and the apoptosis were both increased the in 2-minute CN traction group compared with the control group (P < 0.05). The findings indicate that CN traction is an effective CN injury model and the injury it caused is relatively mild compared with the CN crush model.
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