Immune cell infiltration signatures identified molecular subtypes and underlying mechanisms in gastric cancer.
Immune cell infiltration signatures identified molecular subtypes and underlying mechanisms in gastric cancer.
复制标题
免疫细胞浸润特征揭示了胃癌的分子亚型及潜在机制。
DOI：
10.1038/s41525-021-00249-x
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发表时间：
2021-10-11
影响因子：
5.3
通讯作者：
Shen Z
中科院分区：
文献类型：
--
作者：
Lin Y;Pan X;Zhao L;Yang C;Zhang Z;Wang B;Gao Z;Jiang K;Ye Y;Wang S;Shen Z
Increasing evidence has clarified that the tumor microenvironment (TME) is closely related to the prognosis and therapeutic efficacy of cancer. However, there is no reliable TME evaluation system used to accurately predict the prognosis of and therapeutic efficacy in gastric cancer. We evaluated the immune microenvironment score (IMS) of 1422 gastric cancer samples based on 51 immune cell signatures. We explored the relationship between the IMS and prognosis, immune cell infiltration, cancer subtype, and potential immune escape mechanisms. The results show that activation of the stroma and decreased levels of immune infiltration were associated with a low IMS. A high IMS was characterized by Epstein–Barr virus infection, increased mutation load, microsatellite instability, and immune cell infiltration. A high IMS was also related to high expression of immune checkpoint molecules (PD-1/PD-L1). Finally, patients with a high IMS had a better response to PD-1/PD-L1 inhibitors and may be more suitable for immune checkpoint inhibitors (area under the curve = 0.81). In addition, a low IMS may be converted into the immune-infiltrating subtype after romidepsin treatment. Stratification based on the IMS may enable gastric cancer patients to benefit more from immunotherapy and help identify new cancer treatment strategies.
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DOI：
10.1111/apm.1965.64.1.31
发表时间：
1965-01-01
期刊：
ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA
影响因子：
--
作者：
LAUREN, P
通讯作者：
LAUREN, P
影响因子：
82.9
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
通讯作者：
Krummel MF
影响因子：
4.3
作者：
Cheng WY;Ou Yang TH;Anastassiou D
通讯作者：
Anastassiou D
影响因子：
254.7
作者：
Amin, Mahul B.;Greene, Frederick L.;Winchester, David P.
通讯作者：
Winchester, David P.
影响因子：
28.4
作者：
Fuchs, Charles S.;Doi, Toshihiko;Yoon, Harry H.
通讯作者：
Yoon, Harry H.