Anti-biofilm and remineralization effects of chitosan hydrogel containing amelogenin-derived peptide on initial caries lesions.
Anti-biofilm and remineralization effects of chitosan hydrogel containing amelogenin-derived peptide on initial caries lesions.
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含牙釉蛋白衍生肽的壳聚糖水凝胶对初始龋损的抗生物膜和再矿化作用
DOI：
10.1093/rb/rby005
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发表时间：
2018-03
影响因子：
6.7
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Ren Q;Li Z;Ding L;Wang X;Niu Y;Qin X;Zhou X;Zhang L
在这项研究中，我们设计了一个更强大的临床抗龋齿治疗，通过应用釉原蛋白衍生的肽QP 5的抗菌载体材料壳聚糖在水凝胶（CS-QP 5水凝胶），并表征其对抑制致龋生物膜和促进初始龋齿病变的再矿化的影响。结果表明，CS-QP 5水凝胶可持续地抑制变形链球菌生物膜的生长、乳酸产生和代谢活性，持续时间较长。此外，CS-QP 5水凝胶促进了早期釉质病变的再矿化，这通过表面显微硬度、偏振光显微镜和横向显微放射照相术来指示。总之，CS-QP 5水凝胶在临床上显示出良好的龋齿控制潜力，因为其抗菌作用以及即使在生物膜模型中也能在长时间内使初始釉质龋损再矿化。
In this study, we have designed a more clinically powerful anti-caries treatment by applying the amelogenin-derived peptide QP5 to the antibacterial carrier material chitosan in a hydrogel (CS-QP5 hydrogel), and characterized its effects on the inhibition of a cariogenic biofilm and the promotion of the remineralization of the initial caries lesions. The results indicated that the CS-QP5 hydrogel sustainably inhibited the growth of the Streptococcus mutans biofilm, lactic acid production and the metabolic activity over a prolonged period of time. Moreover, the CS-QP5 hydrogel promoted the remineralization of early enamel lesions, which were indicated by surface micro-hardness (, polarized light microscopy and transverse microradiography. In conclusion, the CS-QP5 hydrogel shows good potential for caries control in the clinic because of its antibacterial effects as well as the remineralization of initial enamel carious lesions even in a biofilm model over a prolonged period of time.
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影响因子：
--
作者：
Burgess, J O;Vaghela, P M
通讯作者：
Vaghela, P M
影响因子：
11.2
作者：
Costa, E. M.;Silva, S.;Pintado, M. M.
通讯作者：
Pintado, M. M.
影响因子：
--
作者：
De Luca MP;Franca JR;Macedo FA;Grenho L;Cortes ME;Faraco AA;Moreira AN;Santos VR
通讯作者：
Santos VR
影响因子：
4.2
作者：
Deng, DM;van Loveren, C;ten Cate, JM
通讯作者：
ten Cate, JM
影响因子：
9.9
作者：
Lee, Hyun-Su;Tsai, Shannon;Composto, Russell J.
通讯作者：
Composto, Russell J.