Postconcussional disorder and PTSD symptoms of military‐related traumatic brain injury associated with compromised neurocircuitry
Postconcussional disorder and PTSD symptoms of military‐related traumatic brain injury associated with compromised neurocircuitry
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与神经回路受损相关的军事相关创伤性脑损伤的脑震荡后障碍和创伤后应激障碍 (PTSD) 症状
DOI：
10.1002/hbm.22358
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发表时间：
2014
影响因子：
4.8
通讯作者：
G. Riedy
中科院分区：
文献类型：
--
作者：
P. Yeh;Binquan Wang;T. Oakes;L. French;H. Pan;J. Graner;Wei Liu;G. Riedy
创伤性脑损伤（TBI）是一种常见的战斗损伤，通常通过爆炸冲击，并产生异质性的脑变化，由于不同的损伤机制。目前还不清楚白色物质的脆弱性是否在冲击伤和冲击伤之间有所不同，并且在军事TBI患者中对神经心理功能的微结构变化的后果知之甚少。扩散张量成像（DTI）技术被用来评估37名美国服务人员（29名轻度，7名中度，1名重度; 17名爆炸和20名非爆炸）的神经回路，他们在部署时持续TBI，与14名未部署的军事对照组相比。MRI弥散张量数据的高维可变形配准之后是纤维跟踪和特定束分析以及感兴趣区分析沿着。DTI结果与脑震荡后和创伤后应激障碍（PTSD）症状有关。爆炸性和非爆炸性患者中最显著的白色微结构损伤位于额纹状体（放射冠、内囊）和额边缘回路（穹窿、扣带回）内的额纤维、额顶枕联合纤维、脑干纤维和胼胝体纤维中。皮质下上级-皮质定向的神经束比非冲击伤更容易受到冲击伤的影响，而直接冲击力对前后定向的神经束有更不利的影响，这往往会导致白色物质连接的不均匀的左右半球不对称。使用弥散各向异性缺陷的纤维束成像显示了皮质-纹状体-丘脑-小脑-皮质（CSTCC）网络，其中脑震荡后和PTSD症状的增加与受损CSTCC神经回路主要节点的低各向异性分数相关，并且还探索了对认知功能的影响。《脑地图》35：2652-2673，2014年。© 2013威利期刊公司.
Traumatic brain injury (TBI) is a common combat injury, often through explosive blast, and produces heterogeneous brain changes due to various mechanisms of injury. It is unclear whether the vulnerability of white matter differs between blast and impact injury, and the consequences of microstructural changes on neuropsychological function are poorly understood in military TBI patients. Diffusion tensor imaging (DTI) techniques were used to assess the neurocircuitry in 37 US service members (29 mild, 7 moderate, 1 severe; 17 blast and 20 nonblast), who sustained a TBI while deployed, compared to 14 nondeployed, military controls. High‐dimensional deformable registration of MRI diffusion tensor data was followed by fiber tracking and tract‐specific analysis along with region‐of‐interest analysis. DTI results were examined in relation to post‐concussion and post‐traumatic stress disorder (PTSD) symptoms. The most prominent white matter microstructural injury for both blast and nonblast patients was in the frontal fibers within the fronto‐striatal (corona radiata, internal capsule) and fronto‐limbic circuits (fornix, cingulum), the fronto‐parieto‐occipital association fibers, in brainstem fibers, and in callosal fibers. Subcortical superior‐inferiorly oriented tracts were more vulnerable to blast injury than nonblast injury, while direct impact force had more detrimental effects on anterior‐posteriorly oriented tracts, which tended to cause heterogeneous left and right hemispheric asymmetries of white matter connectivity. The tractography using diffusion anisotropy deficits revealed the cortico‐striatal‐thalamic‐cerebellar‐cortical (CSTCC) networks, where increased post‐concussion and PTSD symptoms were associated with low fractional anisotropy in the major nodes of compromised CSTCC neurocircuitry, and the consequences on cognitive function were explored as well. Hum Brain Mapp 35:2652–2673, 2014. © 2013 Wiley Periodicals, Inc.
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影响因子：
3.7
作者：
Shirer, W. R.;Ryali, S.;Greicius, M. D.
通讯作者：
Greicius, M. D.
DOI：
10.1073/pnas.93.18.9985
发表时间：
1996-09-03
影响因子：
11.1
作者：
Andreasen, NC;OLeary, DS;Hichwa, RD
通讯作者：
Hichwa, RD
根据研究标准定义，对伴有或不伴有多动症的注意力缺陷障碍进行综合评估。
影响因子：
5.9
作者：
Barkley,RA;DuPaul,GJ;McMurray,MB
通讯作者：
McMurray,MB
DOI：
--
发表时间：
2004-03
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
T. Huisman;L. Schwamm;P. Schaefer;W. Koroshetz;N. Shetty-Alva;Y. Ozsunar;O. Wu;A. Sorensen
通讯作者：
T. Huisman;L. Schwamm;P. Schaefer;W. Koroshetz;N. Shetty-Alva;Y. Ozsunar;O. Wu;A. Sorensen
影响因子：
3.7
作者：
Liston, C;Watts, R;Casey, BJ
通讯作者：
Casey, BJ