Post-training progesterone dose-dependently enhances object, but not spatial, memory consolidation.
Post-training progesterone dose-dependently enhances object, but not spatial, memory consolidation.
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DOI：
10.1016/j.bbr.2008.07.014
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发表时间：
2008-12-12
影响因子：
2.7
通讯作者：
Frick KM
中科院分区：
文献类型：
--
作者：
Harburger LL;Pechenino AS;Saadi A;Frick KM
本研究的目的是确定孕激素是否调节对象和空间记忆巩固在年轻的卵巢切除C57 BL/6小鼠。对象记忆进行了测试，在一个对象识别任务，使用24小时和48小时的延迟。在Morris水迷宫的2天版本中测试空间记忆，其中在训练后24或48小时测试保持。在每个任务中训练后，小鼠立即接受单次腹膜内注射载体或5、10或20 mg/kg水溶性孕酮。然后在24或48小时后在不存在循环孕酮的情况下测试小鼠。训练后注射10和20 mg/kg孕酮增强了物体识别，但在空间水迷宫中没有记忆。这些研究结果表明，对象的记忆巩固在年轻的雌性小鼠是更敏感的孕酮比空间记忆巩固的调节作用，至少使用的任务，剂量和延迟测试。因此，这些发现可能对设计旨在减少与年龄相关的记忆衰退的孕酮疗法具有重要意义。
The aim of this study was to determine if progesterone modulates object and spatial memory consolidation in young ovariectomized C57BL/6 mice. Object memory was tested in an object recognition task using 24- and 48-hr delays. Spatial memory was tested in a 2-day version of the Morris water maze in which retention was tested 24 or 48 hrs after training. Immediately after training in each task, mice received a single intraperitoneal injection of vehicle or 5, 10, or 20 mg/kg water-soluble progesterone. Mice were then tested 24 or 48 hrs later in the absence of circulating progesterone. Post-training injections of 10 and 20 mg/kg progesterone enhanced object recognition, but not memory in the spatial water maze. These findings suggest that object memory consolidation in young female mice is more sensitive to the modulatory effects of progesterone than spatial memory consolidation, at least using the tasks, doses, and delays tested. As such, these findings may have important implications for the design of progesterone therapies intended to reduce age-related memory decline.
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影响因子：
2.9
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通讯作者：
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