The roles of phosphatidylethanol, ethyl glucuronide, and ethyl sulfate in identifying alcohol consumption among participants in professionals health programs.
The roles of phosphatidylethanol, ethyl glucuronide, and ethyl sulfate in identifying alcohol consumption among participants in professionals health programs.
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DOI：
10.1002/dta.2809
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发表时间：
2020-08
影响因子：
2.9
通讯作者：
Lewis B
中科院分区：
文献类型：
--
作者：
Reisfield GM;Teitelbaum SA;Opie SO;Jones J;Morrison DG;Lewis B
直接酒精生物标志物，包括尿乙基葡萄糖醛酸苷（EtG），尿硫酸乙酯（EtS）和血磷脂酰乙醇（PEth），用于监测强制戒酒的个体的戒酒情况。在这个连续的病例系列研究中，我们检查了1000份参与专业健康计划的参与者的法医报告，这些参与者根据合同有义务戒酒，并接受了恢复状态评估。我们确定了52项评估，其中测量了尿EtG，EtS和血液PEth，并对这些分析物中的至少一种产生了阳性结果。PEth，在截止浓度为20 ng/mL，显示酒精使用更频繁比EtG或EtS在我们实验室的截止浓度分别为100和25 ng/mL。在200/50、300/75和400/100 ng/mL的替代EtG/EtS截止浓度下也是如此。在既往诊断为酒精使用障碍（AUD）的参与者中，PEth比EtG/EtS更有可能呈阳性，而在无AUD的参与者中，EtG/EtS比PEth更有可能呈阳性。在这项研究中，血液PEth是证明酒精使用的最敏感的生物标志物。
Direct alcohol biomarkers, including urinary ethyl glucuronide (EtG), urinary ethyl sulfate (EtS), and blood phosphatidylethanol (PEth), are used to monitor alcohol abstinence in individuals who are mandated to abstain. In this consecutive case series study, we examined 1000 forensic reports of participants enrolled in a professionals health program who were contractually obligated to abstain from alcohol and who underwent recovery status evaluations. We identified 52 evaluations in which urinary EtG, EtS, and blood PEth were measured and which produced a positive result for at least one of these analytes. PEth, at a cutoff concentration of 20 ng/mL, revealed alcohol use more frequently than EtG or EtS at our laboratory’s cutoff concentrations of 100 and 25 ng/mL, respectively. This was true, as well, at alternative EtG/EtS cutoff concentrations of 200/50, 300/75, and 400/100 ng/mL. PEth was more likely than EtG/EtS to be positive in participants previously diagnosed with alcohol use disorders (AUD), whereas EtG/EtS was more likely than PEth to be positive in participants without AUD. In this study, blood PEth was the most sensitive biomarker for evidencing alcohol use.
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DOI：
10.1111/acer.12407
发表时间：
2014-07
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Jatlow PI;Agro A;Wu R;Nadim H;Toll BA;Ralevski E;Nogueira C;Shi J;Dziura JD;Petrakis IL;O'Malley SS
通讯作者：
O'Malley SS
DOI：
10.1111/acer.13471
发表时间：
2017-10
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Afshar M;Burnham EL;Joyce C;Clark BJ;Yong M;Gaydos J;Cooper RS;Smith GS;Kovacs EJ;Lowery EM
通讯作者：
Lowery EM
影响因子：
2.9
作者：
Isaksson, Anders;Walther, Lisa;Alling, Christer
通讯作者：
Alling, Christer
影响因子：
2.1
作者：
Baranowski, Stefanie;Serr, Annerose;Halter, Claudia C.
通讯作者：
Halter, Claudia C.
影响因子：
2.5
作者：
Reisfield, Gary M.;Goldberger, Bruce A.;Bertholf, Roger L.
通讯作者：
Bertholf, Roger L.