Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (sandy) mouse.
Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (sandy) mouse.
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DOI：
10.1371/journal.pone.0015886
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发表时间：
2011-01-18
期刊：
影响因子：
3.7
通讯作者：
Tatebayashi Y
中科院分区：
文献类型：
--
作者：
Nihonmatsu-Kikuchi N;Hashimoto R;Hattori S;Matsuzaki S;Shinozaki T;Miura H;Ohota S;Tohyama M;Takeda M;Tatebayashi Y
编码dysbindin的基因的遗传变异一直与精神分裂症和双相情感障碍有关，尽管人们对dysbindin所执行的神经功能知之甚少。为了深入了解这一领域，我们利用现成的dysbindin-null小鼠sandy (sdy−/−)，并使用胸苷类似物溴脱氧尿苷(BrdU)研究海马神经发生。 sdy−/− 和 sdy+/+（对照）小鼠齿状回颗粒下区域祖细胞的增殖（4 小时）或存活（最后一次 BrdU 注射后 1、4 和 8 周）没有发现显着差异。然而，最后一次 BrdU 注射后 4 周，与 sdy+/+ 相比，sdy−/− 中的神经元分化比率显着降低（sdy+/+ = 87.0±5.3% vs. sdy−/− = 71.3±8.3%，p = 0.01）。这些发现表明，dysbindin 在成人海马神经发生的分化过程中发挥作用，其缺陷可能会对神经发生相关功能（如认知和情绪）产生负面影响。
Genetic variations in the gene encoding dysbindin has consistently been associated with schizophrenia and bipolar disorder, although little is known about the neural functions carried out by dysbindin. To gain some insight into this area, we took advantage of the readily available dysbindin-null mouse sandy (sdy−/−) and studied hippocampal neurogenesis using thymidine analogue bromodeoxuridine (BrdU). No significant differences were found in the proliferation (4 hours) or survival (1, 4 and 8 weeks after the last BrdU injection) of progenitors in the subgranular regions of the dentate gyrus between sdy−/− and sdy+/+ (control) mice. However, 4 weeks after the last BrdU injection, a significant reduction was observed in the ratio of neuronal differentiation in sdy−/− when compared to that of sdy+/+ (sdy+/+ = 87.0±5.3% vs. sdy−/− = 71.3±8.3%, p = 0.01). These findings suggest that dysbindin plays a role during differentiation process in the adult hippocampal neurogenesis and that its deficit may negatively affect neurogenesis-related functions such as cognition and mood.
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DOI：
10.1111/j.1601-183x.2009.00477.x
发表时间：
2009-06
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Cox MM;Tucker AM;Tang J;Talbot K;Richer DC;Yeh L;Arnold SE
通讯作者：
Arnold SE
影响因子：
11.9
作者：
Hashimoto, Ryota;Noguchi, Hiroko;Kunugi, Hiroshi
通讯作者：
Kunugi, Hiroshi
影响因子：
3.7
作者：
Okuda H;Kuwahara R;Matsuzaki S;Miyata S;Kumamoto N;Hattori T;Shimizu S;Yamada K;Kawamoto K;Hashimoto R;Takeda M;Katayama T;Tohyama M
通讯作者：
Tohyama M
影响因子：
17.7
作者：
Breen, Gerome;Prata, Diana;Collier, David
通讯作者：
Collier, David
影响因子：
3.5
作者：
Burdick, KE;Lencz, T;Malhotra, AK
通讯作者：
Malhotra, AK