Cerebral intracellular ADP concentrations during hypercarbia: an in vivo 31P nuclear magnetic resonance study in rats.
Cerebral intracellular ADP concentrations during hypercarbia: an in vivo 31P nuclear magnetic resonance study in rats.
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高碳酸血症期间脑细胞内 ADP 浓度：大鼠体内 31P 核磁共振研究。
DOI：
10.1038/jcbfm.1986.64
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
James,TL
中科院分区：
文献类型：
--
作者：
Litt,L;Gonzalez-Mendez,R;Severinghaus,JW;Hamilton,WK;Rampil,IJ;Shuleshko,J;Murphy-Boesch,J;James,TL
在高碳期间，已经在大脑中观察到ADP水平的定性不同反应。一项研究发现，用氟烷麻醉的大鼠在高碳血症期间大脑ADP保持不变，而另一项研究发现，未接受补充麻醉的大鼠在高碳血症期间ADP下降。本文报道了一项体内核磁共振研究，以检验氟烷麻醉导致观察结果差异的假设。异氟醚麻醉也在第二组大鼠中进行了研究，以观察不同的全身麻醉剂是否会产生与氟烷相同的效果。两组5只大鼠经历了两次高碳发作，中间间隔45分钟的恢复期。在第一次发作时给予全身麻醉，0.5%氟烷或1.0%异氟烷，但在第二次发作时不给予全身麻醉。氟烷麻醉时高碳化导致磷酸肌酸（PCr）测量值下降40%，而计算的ADP变化为10%，与前一研究一致。相比之下，异氟醚麻醉或未麻醉时的高碳水化合物仅导致PCr下降10%，这意味着计算出的ADP下降幅度为60%，与第二次研究的结果一致。我们得出结论，在高碳化过程中，氟烷的临床浓度与异氟烷的临床浓度不同，会干扰ATP代谢的调节。
Qualitatively different responses of ADP levels have previously been observed in the brain during hypercarbia. One investigation has found that cerebral ADP stayed constant during hypercarbia in rats that were anesthetized with halothane, while another observed that ADP decreased during supercarbia in rats that received no supplemental anesthesia. This article reports an in vivo31P nuclear magnetic resonance study to test the hypothesis that halothane anesthesia accounts for the discrepant observations. Isoflurane anesthesia was also studied in a second group of rats to see if a different general anesthetic agent would cause the same effects that halothane causes. The two groups of five rats underwent dual episodes of hypercarbia that were separated by a 45-min recovery period. General anesthesia, either 0.5% halothane or 1.0% isoflurane, was administered during the first episode but not during the second. Hypercarbia during halothane anesthesia caused the measured phosphocreatine (PCr) to decrease by 40%, while the calculated change in ADP was 10%, in agreement with the former investigation. In contrast, hypercarbia during either isoflurane anesthesia or no anesthesia caused a decrease of only 10% in PCr, which meant that the calculated decrease in ADP was 60%, in agreement with the results of the second investigation. We conclude that during hypercarbia, clinical concentrations of halothane, unlike clinical concentrations of isoflurane, interfere with the regulation of ATP metabolism.
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