Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity.
Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity.
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DOI：
10.1016/j.physbeh.2010.12.003
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发表时间：
2011-04-18
影响因子：
2.9
通讯作者：
Davidson, Terry L.
中科院分区：
文献类型：
--
作者：
Kanoski, Scott E.;Davidson, Terry L.
饱和脂肪和简单碳水化合物是现代西方饮食的两个主要组成部分，它们的摄入与肥胖和阿尔茨海默病的发展有关。本文总结了研究表明，西方饮食摄入与认知障碍，特别强调学习和记忆功能，是依赖于海马体的完整性。然后，该论文考虑了饱和脂肪和简单碳水化合物摄入与海马神经生物学变化相关的证据，海马神经生物学变化可能与这些饮食成分损害认知功能的能力有关。最后，一个模型的描述提出，西方饮食消费有助于过量的食物摄入和肥胖的发展，在某种程度上，通过干扰一种类型的依赖于记忆抑制，这是至关重要的动物的能力，以避免响应与食物相关的环境线索，并最终从消耗的能量摄入超过驱动的热量需求。
Intake of saturated fats and simple carbohydrates, two of the primary components of a modern Western diet, is linked with the development of obesity and Alzheimer's Disease. The present paper summarizes research showing that Western diet intake is associated with cognitive impairment, with a specific emphasis on learning and memory functions that are dependent on the integrity of the hippocampus. The paper then considers evidence that saturated fat and simple carbohydrate intake is correlated with neurobiological changes in the hippocampus that may be related to the ability of these dietary components to impair cognitive function. Finally, a model is described proposing that Western diet consumption contributes to the development of excessive food intake and obesity, in part, by interfering with a type of hippocampal-dependent memory inhibition that is critical in the ability of animals to refrain from responding to environmental cues associated with food, and ultimately from consuming energy intake in excess of that driven solely by caloric need.
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