Disruptions in cortico-subcortical covariance networks associated with anxiety in new-onset childhood epilepsy.
Disruptions in cortico-subcortical covariance networks associated with anxiety in new-onset childhood epilepsy.
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DOI：
10.1016/j.nicl.2016.10.017
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发表时间：
2016
影响因子：
4.2
通讯作者：
Hermann, Bruce P.
中科院分区：
文献类型：
--
作者：
Garcia-Ramos, Camille;Lin, Jack J.;Bonilha, Leonardo;Jones, Jana E.;Jackson, Daren C.;Prabhakaran, Vivek;Hermann, Bruce P.
焦虑障碍是成人和儿童癫痫患者中普遍存在的精神共病，其病因仍有争议。神经生物学的贡献已经提出，但只有有限的证据表明异常的脑容量，特别是在儿童癫痫和焦虑。由于大脑以有组织的方式发育，不同大脑区域之间的协方差分析可以作为一个网络进行研究，并使用图论方法进行分析。我们检查了46名健康儿童（HC）和青年与最近发生的特发性癫痫（n = 24）和（n = 62）焦虑症。基于85个皮质/皮质下区域的体积之间的协方差的图论（GT）分析进行了研究。与对照组相比，癫痫组和癫痫组在皮质/皮质下体积的同步方面表现出较少的模块间关系，癫痫和焦虑组呈现出最强的模块组织。与对照组相比，非焦虑性癫痫患者的额叶和枕叶区域以及癫痫和焦虑儿童的整个大脑区域显示出最高的中心性。此外，大多数与杏仁核体积相关的节点都是皮层下结构，除了左额叶和右额极，它们呈现出高介数中心性（BC）;因此，它们在网络中的影响不一定是局部的，而是潜在地影响其他更远的区域。总之，近期发作的癫痫和焦虑的儿童表现出大规模的皮质和皮质下大脑区域的破坏。网络科学不仅可以提供对癫痫重要共病的可能神经生物学相关性的洞察，而且还可以提供皮质和皮质下破坏发生的方式。癫痫和焦虑组呈现出最强的模块化组织。额叶和枕区在非焦虑性癫痫中具有较高的中心性。与对照组相比，癫痫发作在整个大脑中具有较高的中心性。左额叶和右额叶是焦虑性癫痫的中枢。焦虑性癫痫患者杏仁核相关的淋巴结多为皮质下结构。
Anxiety disorders represent a prevalent psychiatric comorbidity in both adults and children with epilepsy for which the etiology remains controversial. Neurobiological contributions have been suggested, but only limited evidence suggests abnormal brain volumes particularly in children with epilepsy and anxiety. Since the brain develops in an organized fashion, covariance analyses between different brain regions can be investigated as a network and analyzed using graph theory methods. We examined 46 healthy children (HC) and youth with recent onset idiopathic epilepsies with (n = 24) and without (n = 62) anxiety disorders. Graph theory (GT) analyses based on the covariance between the volumes of 85 cortical/subcortical regions were investigated. Both groups with epilepsy demonstrated less inter-modular relationships in the synchronization of cortical/subcortical volumes compared to controls, with the epilepsy and anxiety group presenting the strongest modular organization. Frontal and occipital regions in non-anxious epilepsy, and areas throughout the brain in children with epilepsy and anxiety, showed the highest centrality compared to controls. Furthermore, most of the nodes correlating to amygdala volumes were subcortical structures, with the exception of the left insula and the right frontal pole, which presented high betweenness centrality (BC); therefore, their influence in the network is not necessarily local but potentially influencing other more distant regions. In conclusion, children with recent onset epilepsy and anxiety demonstrate large scale disruptions in cortical and subcortical brain regions. Network science may not only provide insight into the possible neurobiological correlates of important comorbidities of epilepsy, but also the ways that cortical and subcortical disruption occurs. The group with epilepsy and anxiety presented the strongest modular organization. Frontal and occipital areas had high centrality in non-anxious epilepsy. Anxious epilepsy had high centrality throughout the brain compared to controls. The left insula and the right frontal pole were hubs in anxious epilepsy. Most nodes correlating to amygdala in anxious epilepsy were subcortical structures.
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影响因子：
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作者：
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影响因子：
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DOI：
10.1088/1742-5468/2008/10/p10008
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2008-10-01
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