Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice.
Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice.
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电针通过改善 APP/PS1 小鼠 N-乙酰天冬氨酸和谷氨酸代谢改善学习和记忆
DOI：
10.1186/s40659-018-0166-7
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发表时间：
2018-07-06
影响因子：
6.7
通讯作者：
Tao J
中科院分区：
文献类型：
--
作者：
Lin R;Li L;Zhang Y;Huang S;Chen S;Shi J;Zhuo P;Jin H;Li Z;Liu W;Wang Z;Chen L;Tao J
探讨电针延缓阿尔茨海默病认知功能损害的确切机制。采用磁共振波谱法检测N-乙酰天冬氨酸（NAA）、谷氨酸（Glu）和肌醇（mI）代谢，Morris水迷宫实验和跳台回避实验评价APP/PS 1小鼠学习记忆能力，Nissl染色观察海马神经元存活数和神经元结构，Western blot检测BDNF和磷酸化TrkB。电针DU 20穴可显著改善APP/PS1转基因小鼠的学习记忆能力，上调NAA、Glu和mI代谢，增加海马神经元存活，促进BDNF和TrkB的表达。提示电针可能通过上调APP/PS 1小鼠脑源性神经营养因子（BDNF）的表达，改善NAA和Glu的代谢，从而改善APP/PS 1小鼠的认知功能。
To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. N-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.
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影响因子：
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作者：
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