Circadian regulation of ion channels and their functions.
Circadian regulation of ion channels and their functions.
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DOI：
10.1111/j.1471-4159.2009.06223.x
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发表时间：
2009-08
影响因子：
4.7
通讯作者：
Ko ML
中科院分区：
文献类型：
--
作者：
Ko GY;Shi L;Ko ML
离子通道是神经元兴奋性的守门人。脊椎动物和无脊椎动物的视网膜神经元、脊椎动物的视交叉上核（SCN）神经元和非哺乳类脊椎动物的松果体细胞在其活动中显示每日节律。在单个细胞内具有特定翻译后调节的互锁转录-翻译反馈环形成分子钟，这是维持自主~24小时节律的基本机制。分子钟调节下游输出信号通路，进一步调节各种离子通道的活性。最终，离子通道特性的昼夜节律调节支配这些神经元的兴奋性和行为输出。本文主要介绍了自1980年以来昼夜节律神经生物学研究的最新进展。我们将强调各种离子通道的昼夜节律调节，包括cGMP门控阳离子通道，各种电压门控钙和钾通道，Na+/K+-ATP酶和长开放阳离子通道。这些离子通道的昼夜节律调节及其在各种组织和生物体中的功能的细胞机制也将被讨论。尽管近年来时间生物学研究的规模，离子通道的昼夜节律调节仍然在很大程度上未被探索。通过对离子通道的昼夜节律调节的更多调查和理解，用于治疗睡眠障碍、心血管疾病和与昼夜节律失调相关的其他疾病的治疗策略的未来发展将受益。
Ion channels are the gatekeepers to neuronal excitability. Retinal neurons of vertebrates and invertebrates, neurons of the suprachiasmatic nucleus (SCN) of vertebrates, and pinealocytes of non-mammalian vertebrates display daily rhythms in their activities. The interlocking transcription–translation feedback loops with specific post-translational modulations within individual cells form the molecular clock, the basic mechanism that maintains the autonomic ~24-h rhythm. The molecular clock regulates downstream output signaling pathways that further modulate activities of various ion channels. Ultimately, it is the circadian regulation of ion channel properties that govern excitability and behavior output of these neurons. In this review, we focus on the recent development of research in circadian neurobiology mainly from 1980 forward. We will emphasize the circadian regulation of various ion channels, including cGMP-gated cation channels, various voltage-gated calcium and potassium channels, Na+/K+-ATPase, and a long-opening cation channel. The cellular mechanisms underlying the circadian regulation of these ion channels and their functions in various tissues and organisms will also be discussed. Despite the magnitude of chronobiological studies in recent years, the circadian regulation of ion channels still remains largely unexplored. Through more investigation and understanding of the circadian regulation of ion channels, the future development of therapeutic strategies for the treatment of sleep disorders, cardiovascular diseases, and other illnesses linked to circadian misalignment will benefit.
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Burnside, B;Evans, M;Fletcher, R T;Chader, G J
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CAHILL, GM;BESHARSE, JC
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BESHARSE, JC
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Bailey, MJ;Beremand, PD;Cassone, VM
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Cassone, VM
影响因子：
56.9
作者：
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Schibler, U