A novel mode of chromosomal evolution peculiar to filamentous Ascomycete fungi.
A novel mode of chromosomal evolution peculiar to filamentous Ascomycete fungi.
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DOI：
10.1186/gb-2011-12-5-r45
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发表时间：
2011
期刊：
影响因子：
12.3
通讯作者：
Oliver RP
中科院分区：
文献类型：
--
作者：
Hane JK;Rouxel T;Howlett BJ;Kema GH;Goodwin SB;Oliver RP
基因丢失、倒位、易位和其他染色体重排在物种之间各不相同，导致结构基因组进化的速率不同。在大多数真核生物中，主要的染色体重排是罕见的，在物种之间以相同的顺序和方向产生具有相同基因的大区域。这些大同线性区域对于定位不同物种中的同源基因和指导基因组序列的组装非常有用。以前的真菌分析表明，大同线是罕见的;相反，跨物种的比较显示没有同线或只有通常包含五个或更少基因的微同线区域。为了检验真菌中染色体进化与其他真核生物不同的假设，在主要真菌分类群的物种之间比较了同线性。这些分析确定了一种新的进化形式，其中基因在同源染色体中是保守的，但具有随机的顺序和方向。这种进化模式被称为中同线性，以区别于其他生物中的微观和宏观同线性。中同线是一种不同于大同线保守的替代性进化途径。令人惊讶的是，在所有真菌组中均未发现mesosyntene。相反，mesosynteny似乎仅限于丝状子囊菌，并在Dothideomycetes中的物种之间最引人注目。在亲缘关系较远的子囊菌之间存在中同线性可以用染色体倒位的高频率来解释，但易位一定是极其罕见的。这种现象的机制尚不清楚，但推测涉及减数分裂过程中频繁的倒位。
Gene loss, inversions, translocations, and other chromosomal rearrangements vary among species, resulting in different rates of structural genome evolution. Major chromosomal rearrangements are rare in most eukaryotes, giving large regions with the same genes in the same order and orientation across species. These regions of macrosynteny have been very useful for locating homologous genes in different species and to guide the assembly of genome sequences. Previous analyses in the fungi have indicated that macrosynteny is rare; instead, comparisons across species show no synteny or only microsyntenic regions encompassing usually five or fewer genes. To test the hypothesis that chromosomal evolution is different in the fungi compared to other eukaryotes, synteny was compared between species of the major fungal taxa. These analyses identified a novel form of evolution in which genes are conserved within homologous chromosomes, but with randomized orders and orientations. This mode of evolution is designated mesosynteny, to differentiate it from micro- and macrosynteny seen in other organisms. Mesosynteny is an alternative evolutionary pathway very different from macrosyntenic conservation. Surprisingly, mesosynteny was not found in all fungal groups. Instead, mesosynteny appears to be restricted to filamentous Ascomycetes and was most striking between species in the Dothideomycetes. The existence of mesosynteny between relatively distantly related Ascomycetes could be explained by a high frequency of chromosomal inversions, but translocations must be extremely rare. The mechanism for this phenomenon is not known, but presumably involves generation of frequent inversions during meiosis.
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影响因子：
6.7
作者：
Fisher, Matthew C;Hanage, William P;de Hoog, Sybren;Johnson, Elizabeth;Smith, Michael D;White, Nicholas J;Vanittanakom, Nongnuch
通讯作者：
Vanittanakom, Nongnuch
影响因子：
12.3
作者：
Espagne E;Lespinet O;Malagnac F;Da Silva C;Jaillon O;Porcel BM;Couloux A;Aury JM;Ségurens B;Poulain J;Anthouard V;Grossetete S;Khalili H;Coppin E;Déquard-Chablat M;Picard M;Contamine V;Arnaise S;Bourdais A;Berteaux-Lecellier V;Gautheret D;de Vries RP;Battaglia E;Coutinho PM;Danchin EG;Henrissat B;Khoury RE;Sainsard-Chanet A;Boivin A;Pinan-Lucarré B;Sellem CH;Debuchy R;Wincker P;Weissenbach J;Silar P
通讯作者：
Silar P
影响因子：
7.4
作者：
Friesen, Timothy L.;Zhang, Zengcui;Faris, Justin D.
通讯作者：
Faris, Justin D.
影响因子：
5.1
作者：
Marande, William;Lopez-Garcia, Purificacion;Moreira, David
通讯作者：
Moreira, David
影响因子：
30.8
作者：
Friesen, Timothy L.;Stukenbrock, Eva H.;Oliver, Richard P.
通讯作者：
Oliver, Richard P.