Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study.
Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study.
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DOI：
10.1186/ar3510
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发表时间：
2011
影响因子：
4.9
通讯作者：
Scherjon SA
中科院分区：
文献类型：
--
作者：
van Wyk L;van der Marel J;Schuerwegh AJ;Schouffoer AA;Voskuyl AE;Huizinga TW;Bianchi DW;Scherjon SA
研究表明，胎儿祖细胞在分娩后可在母体血液或骨髓中持续存在30年以上。胎儿细胞的运输增加发生在妊娠并发症期间，如高血压、先兆子痫、流产和宫内生长受限（IUGR）。患有这些妊娠并发症的女性更容易与配偶相容。后来发展为硬皮病的妇女也更经常生下HLA-II类儿童。从这些先前的研究中，我们假设先兆子痫和其他妊娠并发症可能与胎儿细胞运输水平增加有关，并随后参与硬皮病的发展。本研究为回顾性多中心病例对照研究。103名患有系统性硬化症（SSc）的妇女和103名没有SSc或其他自身免疫性疾病病史的妇女接受了关于妊娠期间并发症的问卷调查，如高血压，宫内生长受限（IUGR）和流产。条件Logistic回归分析用于评估相关性。我们发现，与健康对照组相比，有高血压妊娠史或胎儿IUGR的妇女随后发展为SSc的发生率在统计学上显著增加。我们发现，与健康对照组相比，SSc妇女妊娠期高血压并发症的比值比为2.6（95%置信区间（CI）：1.1至4.6），宫内生长受限的比值比为3.9（95% CI：1.2至12.3）。这是第一项研究表明妊娠期高血压并发症或IUGR与以后发生SSc之间的相关性。我们推测妊娠异常可能导致母胎贩运增加，这可能在SSc发病率增加中发挥了作用。进一步的研究表明，以检查这种假定的关系。
Studies have shown that fetal progenitor cells persist in maternal blood or bone marrow for more than 30 years after delivery. Increased trafficking of fetal cells occurs during pregnancy complications, such as hypertension, preeclampsia, miscarriage and intra-uterine growth restriction (IUGR). Women with these pregnancy complications are significantly more often HLA-class II compatible with their spouses. Women who later develop scleroderma also give birth to an HLA-class II child more often. From these prior studies we hypothesized that preeclampsia and other pregnancy complications could be associated with increased levels of fetal cell trafficking, and later be involved in the development of scleroderma. This study was a retrospective multi-centre matched case-control study. One-hundred-and-three women with systemic sclerosis (SSc) and 103 women with no history of SSc or other autoimmune disease were given a questionnaire regarding complications during pregnancy, such as hypertension, intra-uterine growth restriction (IUGR) and miscarriage. Conditional logistic regression analysis was used to assess associations. We found a statistically significantly increased incidence of having had a pregnancy history of hypertension or a fetus with IUGR in women who subsequently developed SSc compared to healthy controls. We found an odds ratio of 2.6 (95% confidence interval (CI): 1.1 to 4.6) for hypertensive complications during pregnancy and an odds ratio of 3.9 (95% CI: 1.2 to 12.3) for intra-uterine growth restriction for women with SSc compared to healthy controls. This is the first study to show an association between hypertensive complications during pregnancy or IUGR and the development of SSc at a later age. We speculate that the pregnancy abnormalities may have resulted in increased fetomaternal trafficking, which may have played a role in the increased incidence of SSc. Further studies are indicated to examine this putative relationship.
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影响因子：
168.9
作者：
Nelson, JL;Furst, DE;Bianchi, DW
通讯作者：
Bianchi, DW
影响因子：
5.1
作者：
Nelson, J. Lee
通讯作者：
Nelson, J. Lee
影响因子：
168.9
作者：
O'Donoghue, K;Chan, J;Fisk, NM
通讯作者：
Fisk, NM
DOI：
10.1073/pnas.93.2.705
发表时间：
1996-01-23
影响因子：
11.1
作者：
Bianchi, DW;Zickwolf, GK;DeMaria, MA
通讯作者：
DeMaria, MA
影响因子：
9.8
作者：
Levine, RJ;Qian, C;Bianchi, DW
通讯作者：
Bianchi, DW