Development and regulation of single- and multi-species Candida albicans biofilms.
Development and regulation of single- and multi-species Candida albicans biofilms.
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DOI：
10.1038/nrmicro.2017.107
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Nobile CJ
中科院分区：
文献类型：
--
作者：
Lohse MB;Gulati M;Johnson AD;Nobile CJ
白色念珠菌是人类微生物群中最普遍的真菌物种之一，并且无症状地在健康个体中定植。然而，它也是一种机会致病菌，可引起严重的，往往是致命的，血液感染。C的医学影响。白色念珠菌通常依赖于其形成生物膜的能力，所述生物膜是附着于表面（例如组织和植入的医疗装置）的紧密堆积的细胞群落。在这篇综述中，我们提供了一个概述的过程中所涉及的形成C。白念珠菌生物膜和讨论的核心转录网络，调节生物膜的发展。我们还考虑了生物膜提供给C.白念珠菌与嗜热生长的比较，并探索由C.白色念珠菌和某些细菌种类。
Candida albicans is among the most prevalent fungal species of the human microbiota and asymptomatically colonizes healthy individuals. However, it is also an opportunistic pathogen that can cause severe, and often fatal, bloodstream infections. The medical impact of C. albicans typically depends on its ability to form biofilms, which are closely packed communities of cells that attach to surfaces, such as tissues and implanted medical devices. In this Review, we provide an overview of the processes involved in the formation of C. albicans biofilms and discuss the core transcriptional network that regulates biofilm development. We also consider some of the advantages that biofilms provide to C. albicans in comparison with planktonic growth and explore polymicrobial biofilms that are formed by C. albicans and certain bacterial species.
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