Investigating disease severity in an animal model of concurrent babesiosis and Lyme disease.
Investigating disease severity in an animal model of concurrent babesiosis and Lyme disease.
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研究疾病严重程度在同时发生的Babesios和莱姆病的动物模型中。
DOI：
10.1016/j.ijpara.2018.06.006
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发表时间：
2019-03
影响因子：
4
通讯作者：
Parveen N
中科院分区：
文献类型：
--
作者：
Bhanot P;Parveen N
在过去的五十年里，巴贝虫病、莱姆病和其他蜱媒疾病的发病率在欧洲和北美稳步上升。田鼠巴氏疏螺旋体是由硬蜱传播的，硬蜱传播莱姆病螺旋体。B。Microti也可以通过输血传播，并且是美国最常见的输血传播感染。硬蜱通常感染两种B。microti和B. burgdorferi，并且是将它们一起传播到宿主中的胜任载体。很少有研究检查了合并感染对人类的影响，这些研究的结果有些矛盾。一项研究将合并感染与B相关联。microti的患者总体症状数量较多，而另一份报告指出，B。伯氏感染既不影响巴贝虫病症状，也不降低其严重程度。小鼠感染模型，表现出类似于在人类巴贝西虫病和莱姆病中观察到的病理效应，提供了一个独特的机会，彻底调查的影响，共感染的主机。莱姆病已经使用易感的C3 H小鼠感染模型进行了研究，该模型也可用于检查B。microti感染，以了解人类疾病的病理机制，无论是在单一感染和合并感染。我们观察到高B。田鼠寄生虫血症导致受感染小鼠的血红蛋白水平降低，反映了在人类巴贝虫病中观察到的贫血。与人类相似，B。microti共同感染似乎增加了小鼠莱姆病样症状的严重程度。共感染小鼠的B峰较低。与感染B的小鼠相比，microti单独，这可能反映了在一些人类合并感染中报告的巴贝虫病症状的减弱。这些结果表明，B。伯氏螺旋体共感染减弱寄生虫生长，而B. microti的存在加剧了小鼠的莱姆病样症状。
The incidence of babesiosis, Lyme disease and other tick-borne diseases has increased steadily in Europe and North America during the last five decades. Babesia microti is transmitted by species of Ixodes, the same ticks that transmit the Lyme disease-causing spirochete, Borrelia burgdorferi. B. microti can also be transmitted through transfusion of blood products and is the most common transfusion-transmitted infection in the U.S.A. Ixodes ticks are commonly infected with both B. microti and B. burgdorferi, and are competent vectors for transmitting them together into hosts. Few studies have examined the effects of coinfections on humans and those have had somewhat contradictory results. One study linked coinfection with B. microti to a greater number of symptoms of overall disease in patients, while another report indicated that B. burgdorferi infection either did not affect babesiosis symptoms or decreased its severity. Mouse models of infection that manifest pathological effects similar to those observed in human babesiosis and Lyme disease offer a unique opportunity to thoroughly investigate the effects of coinfection on the host. Lyme disease has been studied using the susceptible C3H mouse infection model, which can also be used to examine B. microti infection to understand pathological mechanisms of human diseases, both during a single infection and during coinfections. We observed that high B. microti parasitaemia leads to low haemoglobin levels in infected mice, reflecting the anemia observed in human babesiosis. Similar to humans, B. microti coinfection appears to enhance the severity of Lyme disease-like symptoms in mice. Coinfected mice have lower peak B. microti parasitaemia compared to mice infected with B. microti alone, which may reflect attenuation of babesiosis symptoms reported in some human coinfections. These findings suggest that B. burgdorferi coinfection attenuates parasite growth while B. microti presence exacerbates Lyme disease-like symptoms in mice.
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