The interplay between airway epithelium and the immune system - A primer for the respiratory clinician.
The interplay between airway epithelium and the immune system - A primer for the respiratory clinician.
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DOI：
10.1016/j.prrv.2021.03.002
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发表时间：
2021-06
影响因子：
5.8
通讯作者：
Rastogi D
中科院分区：
文献类型：
--
作者：
Weinstock J;Chen XX;Nino G;Koumbourlis A;Rastogi D
呼吸道上皮是人体免疫系统和外部环境之间的主要接口之一。这篇综述讨论了呼吸道上皮的先天和获得性免疫调节作用，强调了与健康相关的生理免疫反应以及当这些生理反应出错时导致疾病的后遗症。呼吸道巨噬细胞、树突状细胞和先天淋巴样细胞是生理性和病理性先天免疫反应的协调者，T细胞、B细胞、肥大细胞和粒细胞(嗜酸性粒细胞和中性粒细胞)是生理性和病理性适应性免疫反应的协调者。讨论了呼吸道上皮和各种免疫细胞之间的相互作用以及这些免疫细胞之间的相互作用，强调了有害刺激和病原体的剂量在免疫编程中的重要性，以及它们与决定免疫反应模式的免疫细胞相互作用的时间。虽然每种细胞类型都被单独研究过，但这篇综述强调了同时对这些不同细胞对有害刺激和病原体的免疫反应进行时间研究的必要性。
The respiratory epithelium is one of the primary interfaces between the body’s immune system and the external environment. This review discusses the innate and adaptive immunomodulatory effects of the respiratory epithelium, highlighting the physiologic immune responses associated with health and the disease-causing sequelae when these physiologic responses go awry. Airway macrophages, dendritic cells, and innate lymphoid cells are discussed as orchestrators of physiological and pathological innate immune responses and T cells, B cells, mast cells, and granulocytes (eosinophils and neutrophils) as orchestrators of physiologic and pathologic adaptive immune responses. The interplay between the airway epithelium and the varied immune cells as well as the interplay between these immune cells is discussed, highlighting the importance of the dose of noxious stimuli and pathogens in immune programming and the timing of their interaction with the immune cells that determine the pattern of immune responses. Although each cell type has been researched individually, this review highlights the need for simultaneous temporal investigation of immune responses from these varied cells to noxious stimuli and pathogens.
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DOI：
10.1084/jem.20101159
发表时间：
2011-09-26
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fuertes MB;Kacha AK;Kline J;Woo SR;Kranz DM;Murphy KM;Gajewski TF
通讯作者：
Gajewski TF
影响因子：
8
作者：
Gurczynski SJ;Zhou X;Flaherty M;Wilke CA;Moore BB
通讯作者：
Moore BB
影响因子：
4.4
作者：
Grayson, Mitchell H.;Ramos, Madeleine S.;Holtzman, Michael J.
通讯作者：
Holtzman, Michael J.
影响因子：
4.3
作者：
Joshi, Nikita;Walter, James M.;Misharin, Alexander V.
通讯作者：
Misharin, Alexander V.
影响因子：
3.6
作者：
Jing, Wei;Wang, Wei;Liu, Qingbin
通讯作者：
Liu, Qingbin