Physicochemical control of adult stem cell differentiation: shedding light on potential molecular mechanisms.
Physicochemical control of adult stem cell differentiation: shedding light on potential molecular mechanisms.
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DOI：
10.1155/2010/743476
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发表时间：
2010
影响因子：
--
通讯作者：
Cho M
中科院分区：
文献类型：
--
作者：
Titushkin I;Sun S;Shin J;Cho M
要实现基于干细胞的生物医学和治疗应用的令人兴奋的潜力，包括组织工程，需要了解细胞-细胞和细胞-环境的相互作用。为此，最近的努力集中在使用诱导可溶性因子、设计合适的机械环境和施加非侵入性物理力量来操纵成体干细胞分化。虽然这些不同的方法都被成功地应用于干细胞分化的调控，但整合和优化结合少数或全部物理化学分化信号以诱导干细胞协同分化将是非常有兴趣和重要的。此外，阐明调节多种分化信号影响的分子机制将使研究人员能够更好地操纵干细胞的行为和反应。
Realization of the exciting potential for stem-cell-based biomedical and therapeutic applications, including tissue engineering, requires an understanding of the cell-cell and cell-environment interactions. To this end, recent efforts have been focused on the manipulation of adult stem cell differentiation using inductive soluble factors, designing suitable mechanical environments, and applying noninvasive physical forces. Although each of these different approaches has been successfully applied to regulate stem cell differentiation, it would be of great interest and importance to integrate and optimally combine a few or all of the physicochemical differentiation cues to induce synergistic stem cell differentiation. Furthermore, elucidation of molecular mechanisms that mediate the effects of multiple differentiation cues will enable the researcher to better manipulate stem cell behavior and response.
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DOI：
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发表时间：
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期刊：
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影响因子：
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