Cerato-platanins: a fungal protein family with intriguing properties and application potential.
Cerato-platanins: a fungal protein family with intriguing properties and application potential.
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DOI：
10.1007/s00253-014-5690-y
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发表时间：
2014-06
影响因子：
5
通讯作者：
Seidl-Seiboth, Verena
中科院分区：
文献类型：
--
作者：
Gaderer, Romana;Bonazza, Klaus;Seidl-Seiboth, Verena
赛拉托铂蛋白是一种小型分泌蛋白，具有四个保守的半胱氨酸，由各种生活方式的丝状真菌大量产生。这些蛋白质似乎很容易被其他生物体识别，因此是真菌与其他生物体相互作用的重要因素，例如真菌。通过刺激植物防御反应的诱导。然而，尚不清楚角铂蛋白的主要功能是否与这些真菌相互作用有关，或者是否与真菌生长和发育中的作用有关。赛拉托铂蛋白似乎统一了其他蛋白中未发现的多种生化特性。一方面，角铂蛋白是碳水化合物结合蛋白，能够与几丁质和N-乙酰氨基葡萄糖寡糖结合；另一方面，它们能够在疏水/亲水界面自组装并形成蛋白质层，例如水溶液表面，从而改变溶液和表面的极性。后一种特性让人想起疏水蛋白，它也是小的、分泌的真菌蛋白，但有趣的是，角铂蛋白的表面活性改变特性与疏水蛋白观察到的特性相反。本综述总结了迄今为止已知的角铂蛋白的生化特性，并讨论了潜在的生物技术应用以及这些特性对角铂蛋白生物学功能的影响。
Cerato-platanin proteins are small, secreted proteins with four conserved cysteines that are abundantly produced by filamentous fungi with all types of lifestyles. These proteins appear to be readily recognized by other organisms and are therefore important factors in interactions of fungi with other organisms, e.g. by stimulating the induction of defence responses in plants. However, it is not known yet whether the main function of cerato-platanin proteins is associated with these fungal interactions or rather a role in fungal growth and development. Cerato-platanin proteins seem to unify several biochemical properties that are not found in this combination in other proteins. On one hand, cerato-platanins are carbohydrate-binding proteins and are able to bind to chitin and N-acetylglucosamine oligosaccharides; on the other hand, they are able to self-assemble at hydrophobic/hydrophilic interfaces and form protein layers, e.g. on the surface of aqueous solutions, thereby altering the polarity of solutions and surfaces. The latter property is reminiscent of hydrophobins, which are also small, secreted fungal proteins, but interestingly, the surface-activity-altering properties of cerato-platanins are the opposite of what can be observed for hydrophobins. The so far known biochemical properties of cerato-platanin proteins are summarized in this review, and potential biotechnological applications as well as implications of these properties for the biological functions of cerato-platanin proteins are discussed.
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